List of Famous people born in Ōsaka Prefecture, Japan

Ayumu Seko is a Japanese footballer who plays for Cerezo Osaka.

Yuji Yaso is a former Japanese football player.

Ryota Hama is a retired Japanese sumo wrestler and current professional wrestler, signed to Big Japan Pro Wrestling in the Strong BJ division.

Kazuhisa Uchihashi is a Japanese guitarist involved in free improvisation music. Born in 1959 in Osaka, Uchihashi began to play the guitar at age 12, playing in various rock bands, though he later studied jazz music. In 1988 he joined the band the First Edition, and in 1990 formed the band Altered States. He was also a member of Otomo Yoshihide's Ground Zero from 1994 to 1997. Uchihashi also plays daxophone, and in addition to his role as a free improviser, Uchihashi has been the musical director for Osaka theatre group Ishinha, has held improvisation workshops in various cities in Japan, as well as London, Oslo, and currently in Vienna also. Uchihashi has set up his own record label, Innocent Records a.k.a. Zenbei Records, had held a music festival annually since 1996 Festival BEYOND INNOCENCE.

Yasuhiko Yabuta is a Japanese former baseball pitcher.

Zachary Herivaux is a Haitian professional footballer who plays as a midfielder for Birmingham Legion in the USL Championship.

Masato Tsujioka is a Japanese actor and filmmaker.

Kenji Kasahara is a Japanese entrepreneur who founded mixi, a social networking site. He is ranked as the 37th richest Japanese person.

Toshio Maeda is an erotic manga artist who was prolific in the 1980s and '90s. Several of Maeda's works have been used as a basis for Original video animations (OVA) including La Blue Girl, Adventure Kid, Demon Beast Invasion, Demon Warrior Koji and his most notorious work, Urotsukidōji. An interviewer commented that Urotsukidōji "firmly placed him in the history books—in Japan and abroad—as the pioneer of the genre known as hentai, or "perverted".

Yusuke Kosai is a Japanese professional baseball infielder for the Tohoku Rakuten Golden Eagles in Japan's Nippon Professional Baseball.