List of Famous people born in Ōsaka Prefecture, Japan

Machiko Satonaka is a Japanese manga artist. She made her professional debut in 1964 during her second year of high school with the one-shot Pia no Shōzō. She has since created nearly 500 manga in a variety of genres. Two of her most notable works are Ashita Kagayaku, which won the 1974 Kodansha Publishing Culture Award, and Karyūdo no Seiza, which won the 1982 Kodansha Manga Award. In addition to creating manga, Satonaka teaches at the Osaka University of Arts as the head of the Character Creative Arts Department and serves on the board of various manga-related organizations in Japan.

Takahiro "Tak" Matsumoto is a Grammy Award-winning Japanese guitarist, producer, arranger, composer, singer and songwriter. In addition to being the guitarist and lead composer for the rock duo B'z, the best-selling music act in their native Japan, he has also had a successful solo career. He is only the fifth guitarist in the world to have his own Gibson signature model guitar. The instrumental album Take Your Pick (2010) made in collaboration with Larry Carlton won an award for the Best Pop Instrumental Album at the 53rd Grammy Awards.

Sana Minatozaki , known mononymously as Sana, is a Japanese singer based in South Korea. She is a member of the girl group Twice, formed by JYP Entertainment. Sana is one of Twice's three Japanese members.

Saburo Kawabuchi is a former Japanese football player and manager. He played for and managed the Japan national team. He is the founder and honorary chairman of the J.League. Between 2002 and 2008 he served as president of the Japan Football Association.

Yoshie Kashiwabara is a Japanese popular pop singer-songwriter and actress, who gained her popularity as a teen idol in the early 80s.

Momiji Nishiya is a Japanese skateboarder and olympian. She competed at the 2020 Summer Olympics in the women's street competition where she won the first ever gold medal in the event. At age 13, she was the the youngest person ever to win a gold medal for Japan.

Yasufumi Terawaki is a Japanese actor. He was nominated for Best Supporting Actor at the 32nd Japan Academy Prize for Aibō The Movie.

Aiko Satō is a Japanese novelist.

Masaya Onosaka is a Japanese voice actor who works for Aoni Production. In 2010 he won the "Best Personality" Seiyu Award.

Katsunari Takayama is a Japanese professional boxer. He is a five-time minimumweight world champion, having held the WBC title in 2005, the IBF title twice between 2013 and 2015, and the WBO title twice between 2014 and 2017. He retired as a professional in 2017, as WBO world champion, to focus on participation in the 2020 Olympics, but returned in 2020 after failing to qualify.