List of Famous people born in Mississippi, United States of America

Marcus L. Dupree is a former American football player. He was born and grew up in Philadelphia, Mississippi, where his playing in high school attracted national attention. A highly touted and sought-after college football recruit, he played at Oklahoma, where he was named Football News Freshman of the Year, second team All-American and Big Eight Conference Newcomer of the Year. He left in the middle of his sophomore season and briefly attended the University of Southern Mississippi. Marcus played spring football for the Golden Eagles and finished college at the university.

Alejandro Villanueva Martínez is an American football offensive tackle for the Pittsburgh Steelers of the National Football League (NFL). Villanueva was a captain in the United States Army, who served in the 2nd Battalion, 87th Infantry Regiment, 10th Mountain Division and later as an Army Ranger in the 1st Battalion, 75th Ranger Regiment. During his time in the U.S. Army, Villanueva was decorated with a Bronze Star for valor. He played college football for the Army Black Knights, being recruited at one position and playing three others during the course of his career. After serving three tours of duty in Afghanistan, he signed a contract with the Philadelphia Eagles on May 5, 2014, after working out in a regional showcase. After being waived by Philadelphia, he was signed by the Pittsburgh Steelers and is currently the team's starting left tackle.

Mathilde "Tig" O'Callaghan Notaro is an American stand-up comic, writer, radio contributor, and actress. She is known for her deadpan comedy. Her acclaimed album Live was nominated in 2014 for the Grammy Award for Best Comedy Album at the 56th Annual Grammy Awards. The special Tig Notaro: Boyish Girl Interrupted was nominated in 2016 at the 68th Primetime Emmy Awards for Outstanding Writing for a Variety Special. In 2017, the album Boyish Girl Interrupted was nominated for the Grammy Award for Best Comedy Album at the 59th Annual Grammy Awards.

Samuel Cook, known professionally as Sam Cooke, was an American singer, songwriter, and entrepreneur. He was also influential as a composer and producer, and is commonly known as the King of Soul for his distinctive vocals and significance in popular music.

Elisha Archibald Manning III is a former American football quarterback who played in the National Football League (NFL) for 13 seasons, primarily with the New Orleans Saints. He was a member of the Saints from 1971 to 1982 and also had brief stints with the Houston Oilers and Minnesota Vikings. In college, he played for the Ole Miss Rebels football team at the University of Mississippi and was inducted into the College Football Hall of Fame in 1989. Manning is the father of Cooper Manning, and former NFL quarterbacks Peyton Manning and Eli Manning.

Ruby Nell Bridges Hall is an American civil rights activist. She was the first African-American child to desegregate the all-white William Frantz Elementary School in Louisiana during the New Orleans school desegregation crisis on November 14, 1960. She is the subject of a 1964 painting, The Problem We All Live With by Norman Rockwell.

Fereydun Robert "Fred" Armisen is an American actor, comedian, writer, producer, and musician best known as a cast member on Saturday Night Live from 2002 until 2013. Armisen has portrayed characters in comedy films, including EuroTrip, Anchorman, and Cop Out. With his comedy partner Carrie Brownstein, Armisen was the co-creator and co-star of the IFC sketch comedy series Portlandia. Armisen founded ThunderAnt.com, a website that features the comedy sketches created with Brownstein, and is the bandleader and frequent drummer for the Late Night with Seth Meyers house band, The 8G Band.

John Neely Kennedy is an American lawyer and politician who has served as the junior United States Senator from Louisiana since 2017. A Democrat turned Republican, he previously served as the Louisiana State Treasurer from 2000 to 2017.

Brandy Rayana Norwood, better known by her mononym Brandy, is an American singer, songwriter, record producer, actress, and businesswoman. Born into a musical family in McComb, Mississippi, Norwood was raised in Carson, California, beginning her career as a backing vocalist for teen groups. After signing with Atlantic Records in 1993, she released her self-titled debut album the following year, which sold six million copies worldwide. In 1996, Norwood began starring in the UPN sitcom Moesha as the title character, which lasted six seasons and resulted in numerous other roles. She resumed her music career in 1998 with the wildly successful duet with fellow R&B contemporary Monica, "The Boy Is Mine", which went on to become one of the best selling female duets of all time. Her second album, Never Say Never, featured two number one singles, and earned Norwood her first Grammy Award.

Margaret LeAnn Rimes Cibrian is an American singer, songwriter, actress, and author. Rimes rose to stardom at age 13 following the release of her version of the Bill Mack song "Blue", becoming the youngest country music star since Tanya Tucker in 1972.