List of Famous people born in Medenine Governorate, Tunisia

Afef Jnifen is a Tunisian Italian fashion model, actress and television presenter.

Taha Yassine Khenissi is a Tunisian professional footballer who plays as a forward for Tunisian top division club ES de Tunis and the Tunisian national team.

René Trabelsi is originally from Djerba, is a businessman and Tunisian politician, also having French nationality.

Samira Merai Friaa is a Tunisian doctor and politician who served as Minister of Public Health from 2016 to 2017.

Ahmed Friaa was the Minister of the Interior of Tunisia for two weeks in January 2011, during the peak of Tunisian revolution.

Ali Laarayedh is a Tunisian politician who was Prime Minister of Tunisia from 2013 to 2014. Previously he served in the government as the Minister of the Interior from 2011 to 2013. Following the resignation of Prime Minister Hamadi Jebali, Laarayedh was designated as Prime Minister in February 2013. He is a member of the Ennahda Movement.

Jamila Debbech Ksiksi is a Tunisian politician from Ennahda. In 2014, she was elected to the Assembly of the Representatives of the People becoming the country's first black female MP.