List of Famous people born in Massachusetts, United States of America

Albert Charles Smith was an American botanist.

Joseph Edward Murray was an American plastic surgeon who performed the first successful human kidney transplant on identical twins Richard and Ronald Herrick on December 23, 1954.

Kenneth Geddes "Ken" Wilson was an American theoretical physicist and a pioneer in leveraging computers for studying particle physics. He was awarded the 1982 Nobel Prize in Physics for his work on phase transitions—illuminating the subtle essence of phenomena like melting ice and emerging magnetism. It was embodied in his fundamental work on the renormalization group.

Matthew Linzee Sands was an American physicist and educator best known as a co-author of the Feynman Lectures on Physics. A graduate of Rice University, Sands served with the Naval Ordnance Laboratory and the Manhattan Project's Los Alamos Laboratory during World War II.

Joseph Story was an American lawyer and jurist who served on the Supreme Court of the United States from 1812 to 1845, during the Marshall Court and early-Taney Court eras. He is most remembered for his opinions in Martin v. Hunter's Lessee and The Amistad case, and especially for his magisterial Commentaries on the Constitution of the United States, first published in 1833. Dominating the field in the 19th century, this work is a cornerstone of early American jurisprudence. It is the second comprehensive treatise on the provisions of the U.S. Constitution and remains a critical source of historical information about the forming of the American republic and the early struggles to define its law.

Richard John Egan was an American business executive, political fundraiser, and United States Ambassador to Ireland (2001–2003).

Ralph Jose P. Burns was an American jazz pianist, composer, and arranger.

Roderick MacKinnon is an American biophysicist, neuroscientist, and businessman. He is a professor of Molecular Neurobiology and Biophysics at Rockefeller University who won the Nobel Prize in Chemistry together with Peter Agre in 2003 for his work on the structure and operation of ion channels.

Dorothy Loudon was an American actress and singer. She won the Tony Award for Best Lead Actress in a Musical in 1977 for her performance as Miss Hannigan in Annie. Loudon was also nominated for Tony Awards for her lead performances in the musicals The Fig Leaves Are Falling and Ballroom, as well as a Golden Globe award for her appearances on The Garry Moore Show.

Paul Efthemios Tsongas was an American politician. He represented Massachusetts in both houses of the United States Congress, holding office from 1975 to 1985. He won eight states as a candidate in the 1992 Democratic presidential primaries, losing the nomination to Bill Clinton.