List of Famous people born in Istanbul, Istanbul Province

Isaac Komnenos or Comnenus was a notable Byzantine aristocrat and military commander in the 1070s. Isaac played a major role in the rise to the throne of his younger brother, the Byzantine Emperor Alexios I Komnenos, and remained a leading figure in his brother's administration until his death.

Isaac Komnenos or Comnenus was the third son of Byzantine Emperor Alexios I Komnenos and Empress Irene Doukaina. He was raised to the high rank of sebastokrator by his older brother John II Komnenos in reward for his support, but they later fell out, as Isaac began to covet the throne.

Theodore I Palaiologos or Palaeologus was Marquis of Montferrat from 1306 until his death.

Constantine Ypsilantis, was the son of Alexander Ypsilanti, a key member of an important Phanariote family, Grand Dragoman of the Porte (1796–99), hospodar of Moldavia (1799–1802) and Walachia (1802–06), and a Prince through marriage to the daughter of Alexandru Callimachi.

Antiochus or Antioch Kantemir or Cantemir was a Moldavian who served as a man of letters, diplomat, and prince during the Russian Enlightenment. He has been called "the father of Russian poetry".

Andronikos Doukas, Latinized as Andronicus Ducas, was a protovestiarios and protoproedros of the Byzantine Empire.

John VIII Palaiologos or Palaeologus was the penultimate Byzantine Emperor, ruling from 1425 to 1448.

Isaac II Angelos was Byzantine Emperor from 1185 to 1195, and again from 1203 to 1204.

Irene Angelina, was a Byzantine princess and member of the Angelos dynasty and by her two marriages Queen of Sicily in 1193 and Queen of Germany from 1198 to 1208.

Constantine V was Byzantine emperor from 741 to 775. His reign saw a consolidation of Byzantine security from external threats. As an able military leader, Constantine took advantage of civil war in the Muslim world to make limited offensives on the Arab frontier. With this eastern frontier secure, he undertook repeated campaigns against the Bulgars in the Balkans. His military activity, and policy of settling Christian populations from the Arab frontier in Thrace, made Byzantium's hold on its Balkan territories more secure.