List of Famous people born in Guatemala Department, Guatemala

Óscar Isaac Hernández Estrada is a Guatemalan-American actor who starred in the tragicomedy Inside Llewyn Davis (2013), for which he received a Golden Globe Award nomination, the crime drama A Most Violent Year (2014), and the science fiction thriller Ex Machina (2014). In 2006, he portrayed Saint Joseph, husband of Mary, in The Nativity Story. He also portrayed José Ramos-Horta, former president of East Timor and co-recipient of the 1996 Nobel Peace Prize, in the Australian film Balibo, for which he won the AACTA Award for Best Actor in a Supporting Role.

Miguel Ángel Asturias Rosales was a Nobel Prize-winning Guatemalan poet-diplomat, novelist, playwright and journalist. Asturias helped establish Latin American literature's contribution to mainstream Western culture, and at the same time drew attention to the importance of indigenous cultures, especially those of his native Guatemala.

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Jimmy Morales is a Guatemalan politician, actor and comedian who served as the 50th president of Guatemala from 2016 to 2020.

Alejandro Eduardo Giammattei Falla is a Guatemalan politician who is the incumbent President of Guatemala. He is a former director of the Guatemalan penitentiary system and participated in Guatemala's presidential elections in 2007, 2011, and 2015. He won in the 2019 election and assumed office on January 14, 2020.

Carlos Humberto Ruiz Gutiérrez, initially nicknamed El Pescadito but gradually known as just Pescado or "Fish", is a retired Guatemalan footballer. A product of CSD Municipal's youth academy, Ruiz has played for five MLS clubs, scoring 88 goals in 182 MLS regular-season matches and 16 goals in the post-season, which is the record for the most post-season goals in MLS history. In 2002, he was named the MLS's Most Valuable Player of the season.

Álvaro Enrique Arzú Yrigoyen was a Guatemalan politician who was the 32nd President of Guatemala from 14 January 1996 until 14 January 2000. He was elected Mayor of Guatemala City on six occasions: in 1982, when he declined taking office because of a coup d'état; in 1986; in 2003, after serving as president; in 2007; in 2011, and in 2015, for a term that would see him die in office.

Margarita Carrera Molina was a Guatemalan philosopher, professor and writer. She was a member of the Academia Guatemalteca de la Lengua and the 1996 laureate of the Miguel Ángel Asturias National Prize in Literature.

Alejandro Baltazar Maldonado Aguirre is a Guatemalan politician who was the Acting President of Guatemala, following the Congress of Guatemala's acceptance of the resignation of President Otto Pérez Molina on September 3, 2015.

Gloria Álvarez Cross is a Guatemalan radio and television presenter, author, and libertarian political commentator. She is the host of the Viernes de Gloria radio program in Guatemala. Álvarez is also the program director of the National Civic Movement of Guatemala, an organization that advocates for political participation in the national politics of Guatemala. She has also published books on political topics for a popular audience.