List of Famous people born in Guairá Department, Paraguay

María Guggiari Echeverría – in religion María Felicia de Jesús Sacramentado – was a Paraguayan Catholic professed religious from the Discalced Carmelite Order who also served in her adolescence as a member of Catholic Action. Echeverría entered the order despite the opposition of her parents and was a close friend of Saua Angel – a friend from Catholic Action who became a priest.

Carlos Gabriel González Espínola is a Paraguayan professional footballer who plays as a forward for Liga MX club Toluca and the Paraguay national team.

Celso Duarte is a virtuoso of Paraguayan harp and Mexican jarocho harp, arranger, singer, and multi-talented instrumentalist. Duarte has performed and recorded with Lila Downs since 1998 and has also accompanied and collaborated with other artists, including Susana Baca, Celso Piña, Plácido Domingo, Mariza, Ramón Vargas, Julieta Venegas, Wynton Marsalis, The Chieftains and Ry Cooder. As a solo artist, he has performed with his band at Carnegie Hall, Kennedy Center, Joe's Pub and other historic venues. His first solo album, "De Sur a Sur ", was released in 2006.

Manuel Ortiz Guerrero was a Paraguayan poet and musician.

Jorge Luis Moreira Ferreira is a Paraguayan footballer who plays as a right back for River Plate.

Cristian Venancio Bogado Morínigo is a Paraguayan footballer who plays as a striker.

Archbishop Edmundo Ponziano Valenzuela Mellid SDB is a Roman Catholic missionary currently serving in Paraguay as the sixth Metropolitan Archbishop of the Archdiocese of Asunción. On February 13, 2006 he was appointed by Pope Benedict XVI as Apostolic Vicar to Chaco Paraguayo, an area with a population of 18,000 but only 5 ordained priests. As a result of this appointment, he was consecrated to the episcopate 22 April 2006. Prior to this appointment, Valenzuela served as a high-profile missionary in Angola. Valenzuela was ordained a priest of the Salesians of Don Bosco in 1977.