List of Famous people born in Centre-Val de Loire, France

René Descartes was a French-born philosopher, mathematician, and scientist who spent a large portion of his working life in the Dutch Republic, initially serving the Dutch States Army of Maurice of Nassau, Prince of Orange and the Stadtholder of the United Provinces. One of the most notable intellectual figures of the Dutch Golden Age, Descartes is also widely regarded as one of the founders of modern philosophy.

Honoré de Balzac was a French novelist and playwright. The novel sequence La Comédie humaine, which presents a panorama of post-Napoleonic French life, is generally viewed as his magnum opus.

Charlotte d'Ornellas is a French conservative journalist and columnist.

Gérard Xavier Marcel Depardieu, CQ is a French actor. He has received acclaim for his performances in The Last Metro (1980), for which he won the César Award for Best Actor, in Police (1985), for which he won the Volpi Cup for Best Actor, Jean de Florette (1986), and Cyrano de Bergerac (1990), winning the Cannes Film Festival for Best Actor, his second César Award for Best Actor, and his first Academy Award nomination for Best Actor. He co-starred in Peter Weir's comedy Green Card (1991), winning a Golden Globe Award and later acted in many big budget Hollywood movies including Ridley Scott's 1492: Conquest of Paradise (1992), Kenneth Branagh's Hamlet (1996), Randall Wallace's The Man in the Iron Mask (1998), and Ang Lee's Life of Pi (2012). He is a Chevalier of the Légion d'honneur and Chevalier of the Ordre national du Mérite. He was granted citizenship of Russia in January 2013, and became a cultural ambassador of Montenegro during the same month.

Philippe Juvin is a French medical doctor and politician of the Republicans (LR) who served as a Member of the European Parliament from 2009 until 2019 for the Île-de-France constituency.

Catherine Nay is a French political columnist and commentator.

Isabelle Geffroy, better known by the nickname Zaz, is a French singer-songwriter who mixes jazzy styles, French variety, soul and acoustic. She is famous for her hit "Je veux", from her first album, Zaz, released on 10 May 2010.

Laure Calamy is a French film and theatrical actress.

Julian Alaphilippe is a French professional road cyclist and cyclocross racer and 2020 UCI road racing world champion, who currently rides for UCI WorldTeam Deceuninck–Quick-Step. He is the brother of racing cyclist Bryan Alaphilippe.

François Alu is a French "Premier Danseur", of the Paris Opera Ballet. He entered the Paris Opera Ballet School in 2004, and the Paris Opera Ballet in 2010. At his first promotion competition, he was promoted to Coryphée, dancing as a free variation the act II solo of Solor, from La Bayadère by Rudolf Nureyev. The next year, he was promoted to "Sujet" (soloist), dancing as a free variation the act III solo of Solor, from La Bayadère by Rudolf Nureyev.