List of Famous people born in Castile-La Mancha, Spain

Pablo Andújar Alba is a professional male tennis player from Spain. Andujar began playing tennis at 6 years old and has won four ATP Tour singles titles, reaching a career-high singles ranking of world No. 32 in July 2015. He trained in Valencia, Spain at the Tennis Club El Collao.

Manuel Marín González was a Spanish politician, former President of the Congress of Deputies of Spain. He was a long-time member of the European Commission, and acting president during the Santer Commission following the resignation of Jacques Santer. He is considered the father of the Erasmus Programme.

José Manuel Arnaiz Díaz is a Spanish professional footballer who plays as a left winger for CD Leganés.

Isabel Rodríguez García is a Spanish politician of the Spanish Socialist Workers' Party (PSOE), serving as Mayor of Puertollano since 2019. She has been a member of the Senate (2003–2007) and the Congress of Deputies (2011–2019).

Marilia Andrés Casares is a Spanish singer-songwriter.

Ana de Mendoza de la Cerda y de Silva Cifuentes, Princess of Eboli, Duchess of Pastrana, was a Spanish aristocrat, suo jure 2nd Princess of Mélito, 2nd Duchess of Francavilla and 3rd Countess of Aliano.

Garcilaso de la Vega, KOS was a Spanish soldier and poet. Although not the first or the only one to do so, he was the most influential poet to introduce Italian Renaissance verse forms, poetic techniques, and themes to Spain. He was well known in poetic circles during his lifetime, and his poetry has continued to be popular without interruption until the present. His poetry was published posthumously by Juan Boscán in 1543, and it has been the subject of several annotated editions, the first and most famous of which appeared in 1574.

Jesús Luis Ocaña Pernía was a Spanish road bicycle racer who won the 1973 Tour de France and the 1970 Vuelta a España. During the 1971 Tour de France he launched an amazing solo breakaway that put him into the Yellow Jersey and stunned the rest of the main field, including back to back Tour champion Eddy Merckx, but abandoned in the fourteenth stage after a crash in the descent of the Col de Menté. Ocaña would abandon many of the Tours that he entered, but he finished in the top 5 of the Vuelta a España on seven occasions.

Rafael Antonio Hernando Fraile is a Spanish attorney and politician who represents Almería Province in the Spanish Congress of Deputies. He was the Sspokesperson of the People's Party in Congress between 2014 and 2018. He has also been the President of New Generations.

Gregorio "Goyo" Benito Rubio was a Spanish footballer who played as a central defender. He spent most of his 16-year professional career with Real Madrid.