List of Famous people born in Castile-La Mancha, Spain

Vicente Cañas, S.J. was a Spanish Christian missionary and Jesuit brother, who is credited with making the first peaceful contact with the Enawene Nawe Indian tribe in 1974. Afterwards, he lived with them for over ten years, adopting their way of life and helping them with necessary medical supplies. Due to his help, the Enawene Nawe population rebounded from a low of 97 individuals to a population of over 430. Similar to Chico Mendes and Wilson Pinheiro, he died at the hands of cattle ranchers who were destroying the Amazon Rainforest.

Manuel Ríos Fernández, known professionally as Manu Ríos, is a Spanish actor and singer known for his role as Patrick Blanco Commerford on the Netflix series Elite.

José Jabardo Zaragoza was a Spanish professional road racing cyclist. He won a stage of the 1942 Vuelta a España, which was only professional victory. He also finished third overall in the previous edition of the race.

Andrés Carrascosa Coso is a Spanish prelate of the Catholic Church who works in the diplomatic service of the Holy See. He has been Apostolic Nuncio to Ecuador since 2017.

Antonio Rivas Martínez is a Spanish retired footballer who played as a central defender, and a manager.

Gil de Albornoz y Espinosa, called Egidio Carillo Albornozio in Italian sources, was a Spanish Catholic Cardinal who led the Spanish delegation at the papal conclave of 1644.

Dr. Alonso Núñez de Haro y Peralta was archbishop of Mexico from September 12, 1772, to May 26, 1800, and viceroy of New Spain from May 8, 1787, to August 16, 1787.