List of Famous people born in Castile and León, Spain

Íñigo López de Mendoza y de la Vega, 1st Marquess of Santillana was a Castilian politician and poet who held an important position in society and literature during the reign of John II of Castile.

Ermengol VI, called el de Castilla, was the Count of Urgell from 1102 to his death. He was the son and successor of Ermengol V and María Pérez, daughter of Count Pedro Ansúrez, Lord of Valladolid, who became his tutor when he was orphaned in 1102.

Bartolomé de la Cueva y Toledo (1499–1562) was a Spanish Roman Catholic cardinal and bishop.

Fernán González was the first autonomous count of Castile. Fernán González was a colourful character of legendary status in Iberia, and founder of the dynasty that would rule a semi-autonomous Castile, laying the foundations for its status as an independent kingdom. In the year 930, Fernán's name appears with the title of count inside the administrative organization of the eastern Kingdom of León.

Alfonso the Innocent was the figurehead of rebelling Castilian magnates against his half-brother Henry IV, who had recognized him as heir presumptive with the title of Prince of Asturias.

Alfonso the Magnanimous was the King of Aragon, Valencia, Majorca, Sardinia and Corsica, Sicily and Count of Barcelona from 1416, and King of Naples from 1442 until his death. He was one of the most prominent figures of the early Renaissance and a knight of the Order of the Dragon.

Mariano Rubio was a Spanish economist who served as the governor of Bank of Spain in the period 1984–1992. He involved in a scandal known as Ibercorp incident and was forced to resign from the office.