List of Famous people born in Castile and León, Spain

Isabella of Castile, Duchess of York was the daughter of King Peter and his mistress María de Padilla. She accompanied her elder sister, Constance, to England after Constance's marriage to John of Gaunt, 1st Duke of Lancaster, and married Gaunt's younger brother, Edmund of Langley, 1st Duke of York.

Juana Enriquez de Córdoba, 5th Lady of Casarrubios del Monte was a Castilian noblewoman and the queen consort of King John II of Aragon from 1458 until her death. As John's wife, she was also de facto Queen of Navarre from 1444. She married John three years after the death of his first wife, Queen Blanche I of Navarre.

Constance of Castile was a claimant to the Crown of Castile. She was the daughter of King Peter, who was deposed and killed by his half-brother, King Henry II. She married the English prince John of Gaunt, who fought to obtain the throne of Castile in her name, but ultimately failed.

Beltrán de la Cueva y Toledo, 3rd Duke of Alburquerque,, was a Spanish nobleman and military leader.

Juan Carlos Higuero Mate is a Spanish middle distance runner, who mostly concentrates on the 1500 metres. He was born in Aranda de Duero, Burgos.

García Álvarez de Toledo y Osorio, 4th Marquess of Villafranca del Bierzo, was a Spanish general and politician.

Pedro Álvarez de Toledo y Zúñiga, jure uxoris Marquess of Villafranca del Bierzo was a Spanish politician. The first effective Spanish viceroy of Naples, in 1532–1552, he was responsible for considerable social, economic and urban improval in the city and southern Italian kingdom in general. He was the father-in-law of Cosimo I de' Medici, Grand Duke of Tuscany.

Alfonso de la Cerda,, called "the disinherited," was the elder son of Ferdinand de la Cerda and his wife Blanche of France, and was a grandson of Alfonso X of Castile. Alfonso and his brother Fernando were candidates for the Castilian-Leonese crown during the reigns of Sancho IV of Castile, Ferdinand IV of Castile and Alfonso XI of Castile. In 1331, Alfonso renounced his rights and swore allegiance to Alfonso XI of Castile.