List of Famous people born in Cali, Colombia

Ximena Duque is a Colombian actress and model.

Luis Mariano Ospina Pérez, commonly known as Mariano Ospina Pérez, was a Colombian politician and a member of the Colombian Conservative Party. He served as the 17th President of Colombia between 1946 and 1950.

Leonardo Fabio Duque is a French-Colombian professional road racing cyclist, who last rode for the Delko team. After stage 19 of the 2009 Tour de France, Duque was named the most combative rider of the stage after aggressively pacing a breakaway. In 2011 he became the first Colombian-born cyclist to finish the cobbled One Day Cycling Monuments, the Tour of Flanders and Paris–Roubaix. He also competed in the men's Madison at the 2004 Summer Olympics.

Juan Francisco Sarasti Jaramillo was a Colombian Roman Catholic archbishop.

Jarlinson Pantano Gómez is a former racing cyclist from Colombia, who rode professionally between 2012 and 2019 for the Colombia, IAM Cycling and Trek–Segafredo teams.

Andrea Lopez is a Colombian actress. She is best known for her antagonistic roles in telenovelas. She is best known for her role as antagonist Mariángel Sánchez de Moncada in Zorro: La Espada y La Rosa (2007).

Andrés Baiz Ochoa, also known as Andi Baiz, is a Colombian film director and screenwriter. As a film director, his first feature was Satanás, based on the book of the same name. He is known also for directing the film The Hidden Face and for the TV series Metástasis and Narcos.

Juana Acosta Restrepo is a Colombian-Spanish actress. She has appeared in more than forty films.

Julio Roberto Valverde Valencia, better known by his stage name Robo, is a Colombian-American drummer. He came to prominence in the early 1980s with punk band Black Flag, and more recently has been a member of Misfits.