List of Famous people born in Antioquia Department, Colombia

Sebastián Pérez Cardona is a Colombian professional footballer who plays as a midfielder for Portuguese Primeira Liga club Boavista.

Yony Alexander González Copete is a Colombian professional footballer who plays as a winger for Portuguese club S.L. Benfica.

Sebastián Villa Cano is a Colombian professional footballer who plays for Boca Juniors.

Fabio Ochoa Vásquez is a former leading member of the Medellín cocaine trafficking cartel, along with his older brothers Juan David and Jorge Luis. His role briefly made him a billionaire. After serving a brief prison term in Colombia, he was arrested and extradited to the US in 1999 and is serving a 30-year term in US federal prison.

Andrés Felipe Robledo Londoño, better known as Reykon "El Líder", is a reggaeton performer from Colombia. He is considered one of the biggest proponents of Latin America's reggaeton music genre. He is from Envigado, Antioquia.

Fernando Gaviria Rendon is a Colombian professional road and track racing cyclist, who currently rides for UCI WorldTeam UAE Team Emirates. He is well known as a sprinter. Riding for the Colombian national cycling team, Gaviria came to international attention at the 2015 Tour de San Luis, where he beat former world champion Mark Cavendish in two sprint finishes. His first major Grand Tour wins came at the 2017 Giro d'Italia. He is the brother of track cyclist Juliana Gaviria. His nickname is "Quetzal splendente", from the brightful and colourful South American bird Quetzal. Its colours recall his world championship titles, his Colombia and "la maglia Ciclamino" won at Giro d'Italia.

Daniel Quintero Calle was born on July 26, 1980, in Medellín (Colombia). He went onto become the youngest elected Mayor of Medellín in October 2019, having previously been a Vice Minister for the national Telecommunications and Information Ministry in Colombia.

Juan Camilo Zúñiga Mosquera is a Colombian former professional footballer who played as a wing-back. Zúñiga has previously played for Italian clubs Siena and Napoli, having won two Coppa Italia titles with the latter; he was also sent on loan by Napoli to Bologna and Watford in 2016. At international level, Zúñiga was part of the Colombia national football team that played in the 2014 FIFA World Cup, and has also represented his nation in three Copa América tournaments.

María Fernanda Yépes Alzate is a Colombian actress and model. She is mostly known for playing Yesica, in the hit Telemundo soap opera Sin Senos no hay Paraíso. She also played the title role in the Colombian television series Rosario Tijeras.

Santigo Tréllez Vivero is a Colombian professional footballer who plays as a striker for Sport Recife, on loan from São Paulo FC.