List of Famous people who died at 22

Abdulaziz al-Omari was a Saudi airport security guard and imam who was one of five hijackers of American Airlines Flight 11 as part of the September 11 attacks.

Huang Wenpan was a Chinese Paralympic swimmer. He won five gold medals at the 2016 Summer Paralympics: at the Men's 50 metre freestyle S3 event with a world record and paralympic record of 39.24, at the Men's 200 metre freestyle S3 event with a world record and paralympic record of 3:09.04, at the Men's 50 metre breaststroke SB2 event with a world record and paralympic record of 50.65 at the Men's 150 metre individual medley SM3 event with a world record and paralympic record of 2:40.19. and at the Mixed 4 x 50 metre freestyle relay 20pts event with a world record and paralympic record of 2:18.03. He also won a silver medal at the Men's 50 metre backstroke S3 event with 46.11.

Tara Fares was a controversial Iraqi model and beauty blogger.

Daan Myngheer was a Belgian cyclist. He died in a hospital two days after suffering a heart attack during the first stage of the 2016 Critérium International.

Colten Boushie was a 22-year-old Indigenous man of the Cree Red Pheasant First Nation who was fatally shot on a rural Saskatchewan farm by its owner, Gerald Stanley. Stanley stood trial for second-degree murder and for a lesser charge of manslaughter, but was ultimately acquitted in February 2018.

Allen R. Schindler Jr. was an American Radioman Petty Officer Third Class in the United States Navy who was murdered for being gay. He was killed in a public toilet in Sasebo, Nagasaki, Japan, by Terry M. Helvey, who acted with the aid of an accomplice, Charles Vins, in what Esquire called a "brutal murder". The case became synonymous with the debate concerning LGBT members of the military that had been brewing in the United States culminating in the "Don't ask, don't tell" bill.

Rafael Henrique Miguel was a Brazilian actor. He was best known for his character Paçoca in the telenovela Chiquititas (2013) and previously for participating in a TV commercial playing a boy who demanded broccoli from his mother in a supermarket. On June 9, 2019, Miguel and his parents were murdered by his girlfriend's father when they arrived at the girl's house to discuss their relationship.

Pedro Pablo Zamora was a Cuban-American AIDS educator and television personality. As one of the first openly gay men with AIDS to be portrayed in popular media, Zamora brought international attention to HIV/AIDS and LGBTQ issues and prejudices through his appearance on MTV's reality television series, The Real World: San Francisco.

On September 16, 2017, Scout Schultz, a 21-year-old student of the Georgia Institute of Technology, was shot once and killed by Tyler Beck, an officer of the Georgia Tech Police Department. Schultz was carrying a multitool and walked towards the police, asking them to shoot. The incident was followed by protests and civil unrest, which led to multiple arrests. Schultz's parents filed a wrongful death suit. The shooting was investigated by the Georgia Bureau of Investigation. In March 2020, it was announced that Tyler Beck would not face charges.

Kostas Georgakis was a Greek student of geology, who, in the early hours of 19 September 1970, set himself ablaze in Matteotti square in Genoa in a fatal protest against the dictatorial regime of Georgios Papadopoulos.