List of Famous people born in Tuscaloosa, United States of America

Deontay Leshun Wilder is an American professional boxer. He held the WBC heavyweight title from 2015 to February 2020, and in doing so became the first American world heavyweight champion in nine years, which was the longest period of time in boxing history without an American heavyweight champion. As of November 2020, he is ranked as the world's second-best active heavyweight by BoxRec, third by the Transnational Boxing Rankings Board, and by The Ring magazine. He has been ranked by BoxRec as the world's top 10 heavyweight since 2012 and as No.2 heavyweight since 2016. His victorious fights against Luis Ortiz received a 5-Star rating each from BoxRec.

Hannah Kelsey Brown is an American television personality and former beauty pageant titleholder. She starred as the eponymous lead in season 15 of The Bachelorette. Brown had previously placed in the top seven in season 23 of The Bachelor. As a beauty pageant titleholder, Brown was crowned Miss Alabama USA 2018, and competed in Miss USA 2018. Following The Bachelorette, she competed on season 28 of Dancing with the Stars with partner, Alan Bersten, and was declared the winner on November 25, 2019.

Lurleen Burns Wallace was the 46th Governor of Alabama for fifteen months from January 1967 until her death in May 1968. She was the first wife of Alabama Governor George Wallace, whom she succeeded as governor because the Alabama constitution forbade consecutive terms. She was Alabama's first female Governor and was the only female governor to hold the position until Kay Ivey became the second woman to succeed to the office in 2017. She is also the only female governor in U.S. history to have died in office. In 1973, she was posthumously inducted into the Alabama Women's Hall of Fame.

Monica Gail Moorehead is an American retired teacher, writer, and political activist. She was the presidential nominee of the Workers World Party (WWP) in 1996, 2000, and 2016.

Debra Gale Marshall is an American actress, and retired professional wrestling valet. Well known by her ring name Debra, she is notable for her appearances with World Championship Wrestling (WCW) as Queen Debra between 1995 and 1998 and the World Wrestling Federation (WWF) as Debra between 1998 and 2002. She began her career in professional wrestling in 1995, accompanying her husband Steve "Mongo" McMichael to the ring in World Championship Wrestling (WCW).

Dylan Riley Jacob Snyder is an American actor. Beginning his acting career in community theatre at the age of five, Snyder is known for his acting, singing, and dancing abilities, starring as Young Tarzan in the 2006 Broadway musical, Tarzan, as Timmy in the 2009 feature film, Life During Wartime and as Milton on the Disney XD comedy series Kickin' It.

Robert Jemison Van de Graaff was an American physicist, noted for his design and construction of high-voltage Van de Graaff generators. He taught at Princeton University and Massachusetts Institute of Technology.

Dinah Washington was an American singer and pianist, who has been cited as "the most popular black female recording artist of the '50s". Primarily a jazz vocalist, she performed and recorded in a wide variety of styles including blues, R&B, and traditional pop music, and gave herself the title of "Queen of the Blues". She was a 1986 inductee of the Alabama Jazz Hall of Fame, and was inducted into the Rock and Roll Hall of Fame in 1993.

Willie D. Burton is an American production sound mixer. His career has spanned five decades and has included films such as The Shawshank Redemption, Se7en, and Indiana Jones and the Last Crusade. Burton has been nominated for the Academy Award for Best Sound or Best Achievement in Sound Mixing a total of seven times, winning twice; he has been nominated for two BAFTA Film Awards for Best Sound, winning once; and he was nominated for one Emmy Award for Outstanding Achievement in Film Sound Mixing for his work on Roots.

Brandon O'Neil Scott is an American actor, voice actor, and producer. He is best known for his roles as Ryan Spalding in the medical drama series Grey's Anatomy (2008–2009), Kohut in the animated comedy film Wreck-It Ralph (2012), Henry in the action-adventure game The Last of Us (2013), Alex in the animated drama series Penn Zero: Part-Time Hero (2015–2017), Jameson in the action-adventure game Uncharted 4: A Thief's End (2016), Coach J.J. Kerba in the teen drama series 13 Reasons Why (2019–2020), Nick Prager in the dark comedy series Dead to Me (2019–present), and Cory Lawrence in the romantic drama series This Is Us (2019–present).