List of Famous people born in Santiago Metropolitan Region, Chile

Cristián Monckeberg Bruner is a Chilean lawyer and politician. He was deputy for the 2006–2018 period, president of Renovación Nacional (2014–2018), three–time minister during the second government of the President Sebastián Piñera (2018–2022) and Constituent Conventional of the Republic of Chile.

Iván Alejandro Moreira Barros is a Chilean politician who currently serves as Senator of the Republic of Chile. An opponent of same-sex marriage, he accused the Chilean government of "bowing to the agenda of the left" in pushing the bill through the parliament in 2021, and accused Sebastián Piñera of abandoning his constituency and the "commitments we had with the world of values."

Fabiola Campillai is a Chilean Senator known for losing her sight in a case of police brutality in the 2019–2022 Chilean protests.

Polimá Ngangu Eduardo Miguel Orellana, known professionally as Polimá Westcoast, is a Chilean rapper and singer. His musical style is defined as Latin trap and reggaeton. He is one of the better known figures of the Chilean urban music scene that emerged in the late-2010s. He had his first underground hit with the song "Brokeboi" in 2018. In 2019 Polimá Westcoast presented a show at Lollapalooza Chile and toured the country soon after.

Marcela Constanza Sabat Fernández is a Chilean lawyer and politician who served as a Senator.