List of Famous people born in Santiago Metropolitan Region, Chile

José Antonio Kast Rist is a Chilean lawyer and politician who served as a member of the Chamber of Deputies, representing District 24 of Peñalolén and La Reina. He was a member of the Independent Democrat Union until 2016, and independent until 2019. Kast ran for president as an independent candidate in the 2017 election, and since 2018 is the leader of the conservative movement Republican Action. In 2019 he created the Chilean Republican Party and the think tank Republican Ideas.

José Pedro Balmaceda Pascal is a Chilean-American actor. He began his career guest starring on various television shows before rising to prominence for portraying Oberyn Martell on the fourth season of the HBO fantasy series Game of Thrones (2014) and Javier Peña on the Netflix biographic crime series Narcos (2015–2017). Pascal has starred as the title character on the Disney+ space Western series The Mandalorian since 2019. Outside of television, he has appeared in the films The Great Wall (2016), Kingsman: The Golden Circle (2017), The Equalizer 2 (2018), Triple Frontier (2019), and Wonder Woman 1984 (2020), and We Can Be Heroes (2020).

Franco Aldo Parisi Fernández is a Chilean business engineer and economist. He received recognition for doing radio and television programs about economy along with his brother Antonino Parisi, and has been nicknamed "the economist of the people". In 2012 he launched his independent candidacy for president for the 2013 elections in Chile. Parisi ideologically identifies himself as a social liberal.

Arturo Erasmo Vidal Pardo is a Chilean professional footballer who plays as a midfielder for Serie A club Inter Milan and the Chile national team. His displays during his time at Juventus led him to be nicknamed Il Guerriero, Rey Arturo and La Piranha by the Italian press due to his hard-tackling and aggressive, tenacious style of play. In Chile, he is also known as Kinnikuman, due to his resemblance to the anime character in the same anime series.

Sebastián Iglesias Sichel Ramírez is a Chilean politician, lawyer and former president of the Banco del Estado de Chile. He previously served as Minister of Social Development and Family and former Executive Vice President of Corfo, under the second government of Sebastián Piñera.

Miguel Juan Sebastián Piñera Echenique is a Chilean billionaire businessman and politician, who has been President of Chile since 2018. He previously served as president from 2010 to 2014.

Marco Antonio Enríquez-Ominami Gumucio is a Chilean-French diplomat, filmmaker, politician, and perennial candidate. From 2006 to 2010 he was a Socialist Party deputy in Chile's lower chamber. In 2009 he quit the party and ran for President of the Republic as independent, where he finished third with 20% of the vote. He is currently the leader of the Progressive Party, which he founded in 2010.

Eduardo Jesús Vargas Rojas is a Chilean professional footballer who plays as a forward for Brazilian club Atlético Mineiro and the Chile national team.

Benjamín Vicuña Luco is a Chilean actor and entrepreneur.

Manuel Luis Pellegrini Ripamonti is a Chilean professional football manager and former player who is the manager of Real Betis. As a coach, he has managed teams in Spain, England, Argentina, Chile, China and Ecuador. Pellegrini has won national leagues in four countries.