List of Famous people born in Santa Fe, Argentina

Héctor Raúl Cúper is an Argentine football manager and former player.

Marcos René Maidana is an Argentine former professional boxer who competed from 2004 to 2014. He was a world champion in two weight classes, having held the WBA (Regular) super lightweight title from 2011 to 2012, and the WBA welterweight title from 2013 to 2014. A versatile brawler in the ring, Maidana was well known for his formidable punching power, and was never stopped in any of his five losses. He famously outbrawled and withstood punishing blows from Floyd Mayweather, Jr. during their first bout, but lost to Mayweather via a highly controversial majority decision.

Carlos Alberto Reutemann, nicknamed "Lole", is an Argentine former racing driver who raced in Formula One from 1972 to 1982, and later became a politician in his native province of Santa Fe, for the Justicialist Party, and governor of Santa Fe in Argentina.

Alberto José Armando was an Argentine businessman and football manager. He was the president of club Boca Juniors from 1954 to 1955, and from 1960 to 1980. With Armando as president, Boca Juniors gained international recognition after winning its first Copa Libertadores and the first Intercontinental Cup in 1977.

Sexual abuse in the Roman Catholic Archdiocese of Santa Fe de la Vera Cruz in Argentina is a major chapter in the series of Catholic sex abuse cases in various Western jurisdictions.