List of Famous people born in Santa Fe Province, Argentina

Lionel Andrés Messi is an Argentine professional footballer who plays as a forward and captains both the Spanish club Barcelona and the Argentina national team. Often considered as the best player in the world and widely regarded as one of the greatest players of all time, Messi has won a record six Ballon d'Or awards and a record six European Golden Shoes. He has spent his entire professional career with Barcelona, where he has won a club-record 33 trophies, including ten La Liga titles, four UEFA Champions League titles and six Copas del Rey. A prolific goalscorer and creative playmaker, Messi holds the records for most goals in La Liga (455), a La Liga and European league season (50), most hat-tricks in La Liga (36) and the UEFA Champions League (8), and most assists in La Liga (185), a La Liga and European league season (21) and the Copa América (12). He has scored over 700 senior career goals for club and country.

Ernesto "Che" Guevara was an Argentine Marxist revolutionary, physician, author, guerrilla leader, diplomat, and military theorist. A major figure of the Cuban Revolution, his stylized visage has become a ubiquitous countercultural symbol of rebellion and global insignia in popular culture.

Emiliano Raúl Sala Taffarel was an Argentine professional footballer who played as a forward.

Mauricio Roberto Pochettino Trossero is an Argentine professional football manager and former player who is the current head coach of Ligue 1 club Paris Saint-Germain.

Marcelo Alberto Bielsa Caldera is an Argentine professional football manager and the current head coach of Premier League club Leeds United. He is also a former player and played as a defender for Newell's Old Boys, Instituto de Córdoba, and Argentino de Rosario.

Mauro Emanuel Icardi is an Argentine professional footballer who plays as a striker for Ligue 1 club Paris Saint-Germain and the Argentina national team.

Ángel Fabián Di María is an Argentine professional footballer who plays for French Ligue 1 club Paris Saint-Germain and the Argentina national team. He can play as either a winger or attacking midfielder.

Jorge Luis Sampaoli Moya is an Argentine football manager who currently manages Clube Atlético Mineiro. Sampaoli started out as a youth player and eventually switched to management after a severe injury. Sampaoli started with an impressive managerial run at Coronel Bolognesi of Peru in 2004, and continued with brief but successful terms at O'Higgins of Chile and Emelec of Ecuador.

Javier Alejandro Mascherano is an Argentine retired professional footballer who played as a defensive midfielder or centre-back.

Santiago Hernán Solari Poggio is an Argentine professional football manager and former player who played as a left midfielder and is currently the manager of Mexican side Club América.