List of Famous people born in Santa Cruz Department, Bolivia

Marcelo Martins Moreno, known as Marcelo Martins in Bolivia and as Marcelo Moreno in other countries, is a Bolivian professional footballer who plays as a striker for Cruzeiro and the Bolivia national football team. He is considered one of the greatest Bolivian strikers of all time. With 21 goals, he is the national team's all-time top goalcorer.

Carlos Emilio Lampe Porras is a Bolivian football goalkeeper who currently plays for Club Always Ready.

Juan Carlos Arce Justiniano is a Bolivian professional footballer who plays for Bolívar.

Luis Fernando Camacho Vaca is a Bolivian lawyer, businessman, activist and politician. He is a member of the Revolutionary Nationalist Movement (MNR) in Bolivia, and has been the chair of the Civic Committee of Santa Cruz since 2019. He emerged as a major critic of President Evo Morales and influential public figure during the highly controversial 2019 Bolivian general election, demanding Morales resign on 5 November 2019.

Henry Vaca Urquiza is a Bolivian professional footballer who plays as an attacking midfielder for The Strongest.

Adriana Salvatierra Arriaza is a Bolivian-Chilean politician. She was the President of the Senate of Bolivia from January 2019 to November 2019. In 2015, she was elected to the Senate as a member of the Movement for Socialism from the Santa Cruz Department.

Branko Marinković Jovičević is a Bolivian-Croatian elechtrochemical engineer, economist, businessman, and politician who served as the Minister of Development Planning and Minister of Economy and Public Finance during the interim presidency of Jeanine Áñez.

Ronald Raldes Balcázar is a former Bolivian football defender. He is the first Bolivian player in history to reach 100 international appearances.

Jhasmani Campos Dávalos is a Bolivian football midfielder who plays for The Strongest.

Oscar Miguel Ortiz Antelo is a Bolivian businessman and politician who served as minister of economy and public finance from July to September 2020 and as minister of productive development from May to July 2020. As a member of the Social Democratic Movement, he previously served two terms as a senator for Santa Cruz from 2015 to 2020 on behalf of the Democratic Unity coalition and from 2006 to 2010 on behalf of the Social Democratic Power alliance. Nearing the end of his second term, Ortiz was his party's presidential candidate, attaining fourth place in the annulled 2019 general elections. During his first term, he served as president of the Senate from 2008 to 2010, the last opposition legislator to preside over the upper chamber as of 2022. Outside of national politics, Ortiz served as president of the Union of Latin American Parties from 2018 to 2021 and has been the rector of the Bolivian Catholic University at Santa Cruz since 2021.