List of Famous people born in Santa Cruz Department, Bolivia

María Desiree Durán Morales is a Bolivian actress, TV Presenter and model who participated in Miss Universe 2006 as Miss Bolivia and made top 10.

Marco Antonio Etcheverry Vargas is a retired Bolivian footballer who played as a forward. A creative playmaker, he is considered one of the greatest Bolivian players of all time. Etcheverry played for D.C. United of Major League Soccer from 1996 to 2003. He helped D.C United win eight trophies during that time, and was nominated to the MLS Best XI in four consecutive seasons from 1996 to 1999.

Hilda Andrade Ordóñez is a female Bolivian football manager.

Germán Busch Becerra was a Bolivian military officer and war hero who served as the 36th president of Bolivia.

Fernando Bascopé Müller is a Bolivian Roman Catholic titular bishop.