List of Famous people born in San Salvador Department, El Salvador

Nayib Armando Bukele Ortez is a Salvadoran politician and businessman who is the 46th and current President of El Salvador who has served since 1 June 2019 after winning the 2019 election. He ran as the candidate of the centre-right GANA party and became the first president since José Napoleón Duarte (1984–1989) not to have been elected as the candidate of one of the country's two major political parties: the FMLN and ARENA. He is also the founder of the political party Nuevas Ideas.

Imanol Uribe is a Spanish screenwriter and film director.

Eeileen Auxiliadora Romero Valle was a Salvadoran lawyer, politician and public servant. A member of the National Coalition Party, she served in the Legislative Assembly of El Salvador from 2018 to 2021.

Baroness Ariane de Rothschild is a French banker, president of the board of the Edmond de Rothschild Group since April 2019. She is the first woman to run a Rothschild-branded financial institution.

Jorge Alberto González Barillas, popularly known as El Mágico, is a Salvadoran former footballer who played mainly as a forward.

Gabriela Roberta Rodríguez de Bukele is a Salvadoran educator, prenatal psychologist and the current first lady of El Salvador, as the wife of the 46th President of El Salvador Nayib Bukele. She is also a professional ballet dancer and is part of the dance company Fundación Ballet de El Salvador.

Alicia Esther Nash was a Salvadoran-American physicist. The wife of mathematician John Forbes Nash, Jr., she was a mental-health care advocate, who gave up her professional aspirations to support her husband and son who were both diagnosed with schizophrenia.

Patricia Escobar de Arzú, also known as Patricia de Arzú, is a Salvadoran-Guatemalan entrepreneur and politician. She is the widow of Former President of Guatemala and mayor of Guatemala City Álvaro Arzú Irigoyen, having served as First Lady of Guatemala from January 14, 1996 to January 14, 2000 and as First Lady of Guatemala City from 1991 to 1996, and again from 2004 until his death in 2018. She was an unsuccessful presidential candidate in the 2011 elections for the Unionist Party.

Armando Calderón Sol was President of El Salvador from June 1, 1994, to June 1, 1999, representing the Nationalist Republican Alliance. He was the first president elected in El Salvador after twelve years of civil war.

Juan Carlos Calleja Hakker is a Salvadoran businessman and politician. He is currently vice president of Grupo Calleja, owner of the largest supermarket chain in El Salvador—and former candidate for President of El Salvador for the Nationalist Republican Alliance (ARENA) for the presidential election of 2019.