List of Famous people born in Pennsylvania, United States of America

George Shiras Jr. was an American lawyer who served as an associate justice of the Supreme Court of the United States from 1892 to 1903. At that time of his appointment, he had 37 years of private legal practice but had never judged a case. He is noted for his votes in Pollock v. Farmers' Loan & Trust Co. and in Plessy v. Ferguson.

Wilkins F. Tannehill (1787–1858) was an American Whig politician and author. He served as the Mayor of Nashville, Tennessee from 1825 to 1827.

Robert John Walker was an American lawyer, economist and politician. An active member of the Democratic Party, he served as a member of the U.S. Senate from Mississippi from 1835 until 1845, as Secretary of the Treasury from 1845 to 1849 during the administration of President James K. Polk, and briefly as Territorial Governor of Kansas in 1857. Robert James Walker (1804–1869), a Senator from Mississippi elected in 1835, was responsible for drafting the 1849 bill that eventually established the U.S. Department of the Interior. As senator, Walker vigorously supported the annexation of Texas. As Secretary of the Treasury, he held responsibility for the management of funds relating to the Mexican–American War,. He contributed to a bill called the Walker tariff, which reduced rates to some of the lowest in history. Walker was appointed Governor of Kansas in 1857 by President James Buchanan but resigned shortly after due to his opposition to the administration-sponsored pro-slavery Lecompton Constitution. After his retirement from politics, Walker supported the United States during the American Civil War and continued to practice law in Washington, D.C.

Isaac Murphy was a native of Pennsylvania, a teacher and lawyer who moved to Fayetteville, Arkansas with his wife and child in 1834. He continued to teach and also became active in politics. Murphy is best known as the only delegate to have repeatedly voted against secession at the second Arkansas Secession Convention in 1861.

Walter Evans Edge was an American diplomat and politician. A Republican, he was twice the Governor of New Jersey, from 1917 to 1919 and again from 1944 to 1947, serving as governor during both World War I and World War II. Edge also served as United States Senator representing New Jersey from 1919 to 1929 and as United States Ambassador to France from 1929 to 1933.

John Joseph Dempsey was a United States Representative from New Mexico who also served as the 13th governor of New Mexico. He was born in White Haven, Pennsylvania, where he attended grade school. Employed as a telegrapher, he held various positions with the Brooklyn Union Elevator Company. He was the vice president of the Brooklyn Rapid Transit Company until 1919 when he entered the oil business in Oklahoma and became vice president of the Continental Oil and Asphalt Company. He moved to Santa Fe, New Mexico, in 1920 and was an independent oil operator and in 1928 became president of the United States Asphalt Company.

William Fisher Packer was an American politician from Pennsylvania who served as the 14th Governor of Pennsylvania from 1858 to 1861.

James Stephenson was an American politician, soldier and slaveholder who as a Federalist served in the Virginia House of Delegates as well as in the United States House of Representatives.

Samuel McKean was an American merchant and politician from Burlington, Pennsylvania who served as a Democratic member of the U.S. Senate for Pennsylvania from 1833 to 1839 and of the U.S. House of Representatives for Pennsylvania's 9th congressional district from 1823 to 1829. He served in the Pennsylvania House of Representatives from 1815 to 1819 and the Pennsylvania State Senate for the 11th district from 1829 to 1830.

Walter Beardsley Tewksbury, was an American track and field athlete. At the 1900 Summer Olympics, he won five medals, including two golds.