List of Famous people born in Mississippi, United States of America

Britney Jean Spears is an American singer, songwriter, dancer, and actress. She is credited with influencing the revival of teen pop during the late 1990s and early 2000s, for which she is referred to as the "Princess of Pop". After appearing in stage productions and television series, Spears signed with Jive Records in 1997 at age 15. Her first two studio albums, certified diamond in the US, ...Baby One More Time (1999) and Oops!... I Did It Again (2000), were global successes and became two of the best-selling albums of all time, along with making her the best-selling teenage artist of all time. The former's title track was named the greatest debut single of all time by Rolling Stone in 2020 and the latter held a 15-year record for fastest-selling album by a female artist in the United States with first-week sales of over 1.3 million copies.

Larry Hoover is an American gang leader, a founder of the Chicago street gang called the Gangster Disciples. Hoover is currently serving six life sentences at the ADX Florence prison in Florence, Colorado. His sentences include a 150–200 year sentence for a 1973 murder; and in 1997, after a 17–year investigation of conspiracy, extortion, money laundering, and running a continuing criminal enterprise for leading the gang from state prison, he received a life sentence.

James Michael Tyler is an American actor best known for his role as Gunther on the NBC sitcom Friends.

Gardner Flint Minshew II is an American football quarterback for the Jacksonville Jaguars of the National Football League (NFL). He played college football at East Carolina before transferring to Washington State, and was drafted by the Jaguars in the sixth round of the 2019 NFL Draft. Following an injury to starter Nick Foles in the opening game of 2019, Minshew took over starting duties until Foles returned later in the year. He took over starting duties again after Foles was benched following poor performance.

Lacey Nicole Chabert is an American actress, voice actress and singer. One of her first roles was playing Erica Kane's daughter on All My Children. She was the third actress to play Bianca Montgomery, playing the part from 1992 until 1993. She then gained prominence as a child actress on television for her role as Claudia Salinger in the television drama Party of Five (1994–2000).

Oprah Gail Winfrey is an American talk show host, television producer, actress, author, and philanthropist. She is best known for her talk show, The Oprah Winfrey Show, broadcast from Chicago, which was the highest-rated television program of its kind in history and ran in national syndication for 25 years from 1986 to 2011. Dubbed the "Queen of All Media", she was the richest African American of the 20th century and North America's first black multi-billionaire, and she has been ranked the greatest black philanthropist in American history. By 2007, she was sometimes ranked as the most influential woman in the world.

Brett Lorenzo Favre is an American former professional football player who was a quarterback in the National Football League (NFL), spending the majority of his career with the Green Bay Packers. He was a 20-year veteran of the NFL, having played quarterback for the Atlanta Falcons in 1991, the Packers from 1992 to 2007, the New York Jets in 2008, and the Minnesota Vikings from 2009 to 2010. Favre was the first NFL quarterback to pass for 500 touchdowns, throw for 70,000 yards, complete 6,000 passes, and attempt 10,000 passes.

DeKaylin Zecharius "DK" Metcalf is an American football wide receiver for the Seattle Seahawks of the National Football League (NFL). He played college football at Ole Miss. He is the son of former NFL guard Terrence Metcalf.

Jamie Lynn Marie Spears is an American actress and singer. She played the role of Zoey Brooks on the Nickelodeon teen sitcom Zoey 101 (2005–2008) and Noreen Fitzgibbons in the Netflix romantic drama series Sweet Magnolias (2020). In 2013, Spears launched a career in country music. She released her debut single, "How Could I Want More", along with her debut EP, The Journey.

James Earl Jones is an American actor whose career spans more than seven decades. He has been described as "one of America's most distinguished and versatile" actors for his performances in film, theater and television, and "one of the greatest actors in American history".