List of Famous people born in Mehedinți County, Romania

Valeriu Tița is a Romanian Former footballer and current coach of Syria national football team. He led Syrian club Al-Ittihad Aleppo to the AFC Cup title in 2010.

Alexander Löhr was an Austrian Air Force commander during the 1930s and, after the annexation of Austria, he was a Luftwaffe commander. Löhr served in the Luftwaffe during World War II, rising to commander of Army Group E and then to commander-in-chief in Southeast Europe.

Mirel Matei Rădoi is a Romanian former footballer and the current head coach of the Romania national team. He played as a defensive midfielder or a central defender. Capped 67 times by the national team, he represented Romania at the UEFA Euro 2008.

Ipolit Strâmbulescu, known as Ipolit Strâmbu, was a Romanian painter best known for his portraits of women, which ranged from domestic scenes to nudes.

Ancuța Bobocel is a Romanian middle-distance runner who specializes in the 3000 metres steeplechase. She represented Romania at the 2008, 2012 and 2016 Summer Olympics and is a three-time participant at the World Championships in Athletics. In 2009, she won the European U23 and Jeux de la Francophonie steeplechase titles, as well as a silver at the Summer Universiade.

Alice Voinescu (1885–1961) was a Romanian writer, essayist, university professor, theatre critic and translator. She was the first Romanian woman to become a Doctor of Philosophy, which she did at the Sorbonne in 1913 in Paris. In 1922, she became a professor of theatrical history at what would become the Royal Academy of Music and Dramatic Arts in Bucharest, where she taught for over two decades. In 1948, she was removed from her department and spent a year and seven months in prisons in Jilava and Ghencea. After her detention, she was kept under house arrest in the village of Costești near Târgu Frumos until 1954. Posthumously, her diary covering the interwar and communist period of Romania's history was discovered and published in 1997.

Flavius Vladimir Stoican is a Romanian professional football coach and former player who is the manager of Liga II club Viitorul Târgu Jiu.

Ion Gigurtu was a far-right Romanian politician, Land Forces officer, engineer and industrialist who served a brief term as Prime Minister from 4 July to 4 September 1940, under the personal regime of King Carol II. A specialist in mining and veteran of both the Second Balkan War and World War I, he made a fortune in interwar Greater Romania. Gigurtu began his career in politics with the People's Party (PP) and the National Agrarian Party, moving closer to the far right during the 1930s, and serving as Minister of Industry and Commerce in the cabinet of Octavian Goga. Shortly after the start of World War II, Gigurtu was affiliated with King Carol's National Renaissance Front, serving as Public Works and Communications Minister and Foreign Minister under Premier Gheorghe Tătărescu, before the territorial losses incurred by Romania in front of the Soviet Union propelled him as Tătărescu's replacement.