List of Famous people born in KwaZulu-Natal, South Africa

Patrick van Rensburg was a South African-born anti-apartheid activist and educator. In the 1960s he founded Swaneng Hill School in Serowe, Botswana, and the nationwide Brigades Movement in that country. In the 1980s he founded the Mmegi national newspaper and the Foundation for Education with Production, which promoted his ideas in South Africa, Botswana, and Zimbabwe. In 1981, he was awarded the Right Livelihood Award "for developing replicable educational models for the third world majority".

Mantombazana 'Manto' Edmie Tshabalala-Msimang was a South African politician. She was Deputy Minister of Justice from 1996 to 1999 and served as Minister of Health from 1999 to 2008 under President Thabo Mbeki. She also served as Minister in the Presidency under President Kgalema Motlanthe from September 2008 to May 2009.

Mondli Cele was a South African association football midfielder. He played his career only in South Africa, and died in a car accident near Pietermaritzburg.

Mzilikazi Khumalo was a Southern African king who founded the Mthwakazi Kingdom now known as Matebeleland, in what became British South Africa Company-ruled Rhodesia and is now Zimbabwe. His name means "the great road". He was born the son of Mashobane kaMangethe near Mkuze, Zululand, and died at Ingama, Matebeleland. Many consider him to be the greatest Southern African military leader after the Zulu king Shaka. In his autobiography, David Livingstone referred to Mzilikazi as the second most impressive leader he encountered on the African continent.

Sean William Dundee is a former professional footballer who played as a striker. Born in South Africa, Dundee represented Germany national B team once.

Delron Sebastian Buckley is a South African former professional footballer. His preferred position was the left wing although he could also play as a striker.

Nozizwe Charlotte Madlala-Routledge is a South African politician who was South Africa's Deputy Minister of Defence from 1999 to April 2004 and Deputy Minister of Health from April 2004 to August 2007. President Thabo Mbeki dismissed her from the Cabinet on 8 August 2007, after which she maintained her role as a member of parliament representing the African National Congress. On 25 September 2008, she became Deputy Speaker of the National Assembly, serving in that capacity until resigning from Parliament in early May 2009. She has been a member of the South African Communist Party since 1984.

Musetta Vander is a South African actress, model and dancer.

Willem Hendrik Jacques "Sheep" du Plessis is a South African rugby union player, currently playing in France with the French Top 14 side Montpellier. His regular positions are flanker or lock.

Candice "Kandyse" McClure is a South African-born Canadian actress. She has played Anastasia Dualla on the Sci Fi Channel's television program Battlestar Galactica, and Dr. Clementine Chasseur on the Netflix original series Hemlock Grove.