List of Famous people born in Greater Accra Region, Ghana

Derek Owusu Boateng is a retired Ghanaian professional footballer who played as a defensive midfielder. Born in Ghana, Boateng went on to play professional football in Greece, Sweden, Israel, Germany, Spain, Ukraine, England, and the United States. He won 47 caps for the Ghana national team and represented his country at the 2006 and 2010 FIFA World Cups.

Daniel Amartey is a Ghanaian professional footballer who plays as a defender or midfielder for Premier League club Leicester City and the Ghana national team.

Daniel Tawiah Opare is a Ghanaian professional footballer who plays as a right-back for S.V. Zulte Waregem and the Ghana national team.

Hugh Anthony Quarshie is a Ghanaian-born British actor. Some of his best-known roles include his appearances in the films Highlander (1986), The Church (1989), Star Wars: Episode I – The Phantom Menace (1999), and the Doctor Who episodes "Daleks in Manhattan" and "Evolution of the Daleks" (2007) as well as his long-running role as Ric Griffin in the BBC medical drama Holby City (2001–2020). Quarshie played the role of Ric for 19 years and was the longest-serving cast member in Holby City, until he confirmed his departure in October 2020. The character departed in Episode 1034 of Series 22, which aired on 10 November 2020.

Kasim Adams Nuhu, also known simply as Kasim, is a Ghanaian professional footballer who plays as a centre back for German club 1899 Hoffenheim.

Peter Mensah is a Ghanaian-British actor, best known for his roles in the films Tears of the Sun, Hidalgo, 300, and television series such as Starz' Spartacus: Blood and Sand, Spartacus: Gods of the Arena, and Spartacus: Vengeance.

Isaac Cofie is a Ghanaian professional footballer who plays as a midfielder for Sivasspor.

Brimah Razak is a Ghanaian professional footballer who plays for Spanish club Linares Deportivo as a goalkeeper.

Margaret Yvonne Busby,, Hon. FRSL, also titled Nana Akua Ackon, is a Ghanaian-born publisher, editor, writer and broadcaster, resident in the UK. She was Britain's youngest and first black female book publisher when in the 1960s she co-founded with Clive Allison (1944–2011) the London-based publishing house Allison and Busby. She edited the anthology Daughters of Africa (1992), and its 2019 follow-up New Daughters of Africa. She is a recipient of the Benson Medal from the Royal Society of Literature. In 2020 she was voted one of the "100 Great Black Britons".

Gamal Gorkeh Nkrumah is a Ghanaian journalist, a Pan-Africanist and an editor of Al Ahram Weekly newspaper. He is the eldest son of the first president of Ghana, Kwame Nkrumah, and his Egyptian wife Fathia Nkrumah.