List of Famous people born in Grand Est, France

Dominique Desseigne is a French businessperson. He is the chief executive of Groupe Lucien Barrière.

Jonathan Clauss is a French professional footballer who plays as a right-back for Ligue 1 club RC Lens.

Robert Emmanuel Pires is a French football coach and former professional player.

Yannick Noah is a former professional tennis player and singer from France. He won the French Open in 1983, and is currently the captain of both France's Davis Cup and Fed Cup team. During his career, which spanned almost two decades, Noah captured a total of 23 singles titles and 16 doubles titles, reaching a career-high singles ranking of world No. 3 in July 1986 and attaining the World No. 1 doubles ranking the following month. Since his retirement from the game, Noah has remained in the public eye as a popular music performer and as the co-founder, with his mother, of a charity organization for underprivileged children. Noah is also the father of NBA player Joakim Noah.

Mark Randall Meadows is an American politician who served as the 29th White House chief of staff from 2020 to 2021. He served as the U.S. representative for North Carolina's 11th congressional district from 2013 to 2020. A member of the Republican Party, Meadows chaired the House Freedom Caucus from 2017 to 2019. He was considered one of President Donald Trump's closest allies in Congress before his appointment as chief of staff.

Annelise Hesme is a French actress. Her older sister Élodie Hesme and younger sister Clotilde Hesme are also actresses.

Pierre Deladonchamps is a French actor. He is known for starring in the thriller film Stranger by the Lake (2013), for which he won the César Award for Most Promising Actor. He went on to receive a nomination for the César Award for Best Actor for his performance in the drama A Kid (2016). He received the Chevalier of the Order of Arts and Letters by the Government of France in 2015.

Morgan Fernand Gérard Schneiderlin is a French professional footballer who plays as a defensive midfielder for Nice and the France national team.

Élodie Gossuin is a French beauty pageant titleholder, model, radio and television presenter, columnist and regional politician. She was elected Miss Picardy 2000, Miss France 2001, and Miss Europe 2001. Since 2016, she has been the French voting spokesperson in the Eurovision Song Contest.

Karl Brandt was a German physician and Schutzstaffel (SS) officer in Nazi Germany. Trained in surgery, Brandt joined the Nazi Party in 1932 and became Adolf Hitler's escort doctor in August 1934. A member of Hitler's inner circle at the Berghof, he was selected by Philipp Bouhler, the head of Hitler's Chancellery, to administer the Aktion T4 euthanasia program. Brandt was later appointed the Reich Commissioner of Sanitation and Health. Accused of involvement in human experimentation and other war crimes, Brandt was indicted in late 1946 and faced trial before a U.S. military tribunal along with 22 others in United States of America v. Karl Brandt, et al. He was convicted, sentenced to death, and later hanged on 2 June 1948.