List of Famous people born in Granada Department, Nicaragua

Ernesto Cardenal Martínez was a Nicaraguan Catholic priest, poet, and politician. He was a liberation theologian and the founder of the primitivist art community in the Solentiname Islands, where he lived for more than ten years (1965–1977). A former member of the Nicaraguan Sandinistas, he was Nicaragua's minister of culture from 1979 to 1987. He was prohibited from administering the sacraments in 1984 by Pope John Paul II, but rehabilitated by Pope Francis in 2019.

Fernando Cardenal Martínez was a Nicaraguan Jesuit and liberation theologian.

Pedro Joaquín Chamorro Cardenal was a Nicaraguan journalist and publisher. He was the editor of La Prensa, the only significant opposition newspaper to the long rule of the Somoza family. He is a 1977 laureate of the Maria Moors Cabot Prize of the University of Columbia. He married Violeta Barrios de Chamorro who later went on to become President of Nicaragua (1990-1996). In 1978, he was shot to death, one of the precipitating events of the overthrow of the Somoza regime the following year.

René Enríquez was a Nicaraguan-born American television actor of the 1970s and 1980s. He is best-remembered for his role as Lt. Ray Calletano in the long-running television series Hill Street Blues (1981–1987).

José María Estrada was the President of Nicaragua under Fruto Chamorro’s command to direct the war, from 12 March to 23 October 1855.