List of Famous people born in Clarksdale, United States of America

William Leonard Roberts II, known professionally as Rick Ross, is an American rapper, songwriter, entrepreneur, and record executive.

Samuel Cook, known professionally as Sam Cooke, was an American singer, songwriter, and entrepreneur. He was also influential as a composer and producer, and is commonly known as the King of Soul for his distinctive vocals and significance in popular music.

Izear Luster "Ike" Turner Jr. was an American musician, bandleader, songwriter, arranger, talent scout, and record producer. An early pioneer of 1950s rock and roll, he is best known for his work in the 1960s and 1970s with his then-wife Tina Turner in the Ike & Tina Turner Revue.

Nathaniel Dwayne Hale, better known by his stage name Nate Dogg, was an American singer, rapper and songwriter. Recognisable for his deep singing voice, Hale became best known for providing guest vocals for a multitude of hit rap songs between 1994 and 2007, earning the nickname "King of Hooks".

Terrence Orlando Metcalf is a former American college and professional football player who was a guard in the National Football League (NFL) for seven seasons during the early 2000s. He played college football for the University of Mississippi, and was recognized as a consensus All-American. The Chicago Bears chose him in the third round of the 2002 NFL Draft. His son DK Metcalf is an All-Pro wide receiver for the Seattle Seahawks.

Raymond Earl Hill was an American tenor saxophonist and singer, best known as a member of Ike Turner's Kings of Rhythm in the 1950s. He also recorded as a solo artist for Sun Records and worked as a session musician.

Herman "Junior" Parker was an American Memphis blues singer and musician. He is best remembered for his voice which has been described as "honeyed" and "velvet-smooth". One music journalist noted, "For years Junior Parker deserted downhome harmonica blues for uptown blues-soul music". In 2001, he was inducted into the Blues Hall of Fame. Parker is also inducted into the Mississippi Musicians Hall of Fame.

Jackie Brenston was an American R&B singer and saxophonist, who recorded, with Ike Turner's band, the first version of the pioneering rock-and-roll song "Rocket 88".

John Lee Hooker was an American blues singer, songwriter, and guitarist. The son of a sharecropper, he rose to prominence performing an electric guitar-style adaptation of Delta blues. Hooker often incorporated other elements, including talking blues and early North Mississippi Hill country blues. He developed his own driving-rhythm boogie style, distinct from the 1930s–1940s piano-derived boogie-woogie. Hooker was ranked 35 in Rolling Stone's 2015 list of 100 greatest guitarists.