List of Famous people born in Castile-La Mancha, Spain

Juan José Asenjo Pelegrina is the Roman Catholic Archbishop of Seville, since his appointment by Pope Benedict XVI on 5 November 2009.

Francisco Luzón López was a Spanish banker and economist. He assisted in transforming Spanish and Latin American banking over the last thirty years, leading banks such as Banco Bilbao Vizcaya Argentaria and Banco Santander. Luzón was diagnosed with ALS in October 2013 and created the Fundación Francisco Luzón to fund ALS research.

Saint Hermenegild or Ermengild, was the son of king Liuvigild of the Visigothic Kingdom in the Iberian Peninsula and southern France. He fell out with his father in 579, then revolted the following year. During his rebellion, he converted from Arianism to Chalcedonian Christianity. Hermenegild was defeated in 584 and exiled. His death was later celebrated as a martyrdom due to the influence of Pope Gregory I's Dialogues, in which he portrayed Hermenegild as a "Catholic martyr rebelling against the tyranny of an Arian father."

Carlos Seco Serrano was a Spanish historian who specialised in the contemporary era.

Francisco Javier Cerezo Perales, known as Francisco Cerezo for short, is a Spanish former professional road bicycle racer.