List of Famous people born in Castile and León, Spain

Mark Eugene Russinovich is a Spanish-born American software engineer who serves as CTO of Microsoft Azure. He was a cofounder of software producers Winternals before it was acquired by Microsoft in 2006.

Jesús Hernández Blázquez is a Spanish former road bicycle racer, who competed professionally between 2004 and 2017, for the Liberty Seguros–Würth, Relax–GAM, Astana, Tinkoff and Trek–Segafredo teams. He now works as a directeur sportif for UCI Continental team Eolo–Kometa.

David Navas Chica is a Spanish professional road bicycle racer.

Francisco-Javier Lozano Sebastián is a Spanish prelate of the Catholic Church who has spent his career in the diplomatic service of the Holy See. He has been an archbishop since 1994 and held the title of Apostolic Nuncio to several countries until his resignation in 2015.

Juan Vicente Herrera Campo is a Spanish politician who served as President of the Junta of Castile and León from 2001 to 2019 and a member of the conservative People's Party.