List of Famous people born in Antofagasta Region, Chile

Alexis Alejandro Sánchez Sánchez, also known simply as Alexis, is a Chilean professional footballer who plays as a forward for Serie A club Inter Milan and the Chile national team. He is popularly dubbed "El Niño Maravilla".

Erick Antonio Pulgar Farfán is a Chilean professional footballer who plays for Serie A side Fiorentina. Mainly a defensive midfielder, he can also play as a defender.

Alejandro Jodorowsky Prullansky is a Chilean-French filmmaker and artist. Since 1948, Jodorowsky has worked as a novelist, screenwriter, a poet, a playwright, an essayist, a film and theater director and producer, an actor, a film editor, a comics writer, a musician and composer, a philosopher, a puppeteer, a mime, a lay psychologist, a draughtsman, a painter, a sculptor, and a spiritual guru. Best known for his avant-garde films El Topo (1970) and The Holy Mountain (1973), he has been "venerated by cult cinema enthusiasts" for his work which "is filled with violently surreal images and a hybrid blend of mysticism and religious provocation".

María Lucía Hiriart Rodríguez, also known as Lucía Hiriart de Pinochet, is the widow of former Chilean dictator Augusto Pinochet.

Guillermo Alejandro Pallomari González, nicknamed Reagan, is a Chilean accountant who worked for the Cali Cartel and participated in a scandal involving financial fraud during the 1994 Colombian presidential election, that bestowed Ernesto Samper, as winner of the respective elections. Pallomari is currently under the Witness Protection Program of the United States.

The case of Fernando Karadima concerned the sexual abuse of minors in Chile, which became public in 2010. It raised questions about the responsibility and complicity of several Chilean bishops, including some of the country's highest-ranking Catholic prelates. By 2018, it attracted worldwide attention.

Andrónico Luksic Craig is a businessman and chairman of Quiñenco, a holding of the Luksic Group, one of Chile's largest conglomerates.

Tonka Tomicic Petric audio (help·info) is a Chilean model and television presenter of Croatian origin.

Ángelo Giovanni Araos Llanos is a Chilean footballer who plays as an attacking midfielder for Brazilian Série A club Corinthians.

Neven Ilic is a Chilean engineer and sports official that was born on 4 April 1962 in Antofagasta, Chile.