List of Famous people born in Antioquia Department, Colombia

Santiago Escobar Saldarriaga is a Colombian football manager and former player who played as a defensive midfielder. He is the brother of the murdered footballer Andrés Escobar. Following his retirement from football, he became a football manager; he is known for leading Atlético Nacional to win the 2005 and 2011 Categoría Primera A. He also won the 2010 Copa Aerosur with Club Bolívar.

Jorge Luis Ochoa Vásquez is a Colombian drug trafficker who was one of the key founding members of the notorious Medellín Cartel in the late 1970s. The cartel's key members were Pablo Escobar, Carlos Lehder, José Gonzalo Rodríguez Gacha, Gustavo Gaviria, Jorge Ochoa and his brothers Juan David and Fabio.

Hernán Darío Gómez Jaramillo, also known as El Bolillo, is a Colombian former footballer and football manager who is currently the head coach of Colombian club Independiente Medellín.

Álvaro Uribe Vélez is a Colombian politician who served as the 31st President of Colombia from 7 August 2002 to 7 August 2010.

Edwin Andrés Cardona Bedoya is a Colombian professional footballer who plays for Boca Juniors and for the Colombian national team.

Mariana Pajón Londoño ODB is a Colombian cyclist, two-time Olympic gold medalist and BMX World Champion.

Sergio Fajardo Valderrama is a Colombian politician and mathematician. Fajardo served as the Governor of Antioquia from 2012–2016. He first entered politics in 2003 when he was elected Mayor of Medellin, the second-largest city in Colombia and the capital of Antioquia. Fajardo was the Vice Presidential nominee of Antanas Mockus in 2010, finishing in second place after losing the runoff against Juan Manuel Santos and Angelino Garzon. Fajardo brands himself as a pragmatic politician with no particular ideology, with political analysts and media outlets in Colombia labelling him as a centrist politician not tied to the traditional parties in Colombia.

Juan Esteban Aristizábal Vásquez, known professionally as Juanes, is a Colombian musician and singer-songwriter who was a member of the rock band Ekhymosis and is now a solo artist. In 2000, his solo debut album Fíjate Bien won three Latin Grammy Awards. According to his record label, Juanes has sold more than 15 million albums worldwide.

Fernando Botero Angulo is a Colombian figurative artist and sculptor, born in Medellín. His signature style, also known as "Boterismo", depicts people and figures in large, exaggerated volume, which can represent political criticism or humor, depending on the piece. He is considered the most recognized and quoted living artist from Latin America, and his art can be found in highly visible places around the world, such as Park Avenue in New York City and the Champs-Élysées in Paris.

Rigoberto Urán Urán, ODB is a Colombian professional road racing cyclist, who currently rides for UCI WorldTeam EF Education–Nippo.