List of Famous people who died at 21

Tyler Scott Haun Hilinski was an American football quarterback who played college football at Washington State University. He died by suicide following his junior year. An autopsy revealed that he had stage one chronic traumatic encephalopathy (CTE).

Claire Lucia Wineland was an American activist, author, TEDx Speaker and a social media personality. Through her non-profit organization, Claire's Place Foundation, she provided support to children and families affected by cystic fibrosis (CF). She died from a stroke one week after a lung transplant at the age of 21.

Desiet Kidane was an Eritrean professional racing cyclist, who rode for UCI Women's Continental Team WCC Team. She rode in the women's road race at the 2019 UCI Road World Championships in Yorkshire, England.

Brandon Teena was an American trans man who was raped and later, along with Phillip DeVine and Lisa Lambert, murdered in Humboldt, Nebraska. His life and death were the subject of the films The Brandon Teena Story and Boys Don't Cry. They also illustrated that legal and medical discrimination contributed to Teena's violent death.

Siasau "Sal" Aunese was a college football player who played for the University of Colorado. Aunese was from Oceanside, California in San Diego County and was of Samoan descent. He died at age 21 from inoperable stomach cancer and lung cancer.

Travon DaShawn Frank Smart, better known by his stage name Jimmy Wopo, was an American rapper from Pittsburgh, Pennsylvania.

Nodar Kumaritashvili was a Georgian luge athlete who suffered a fatal crash during a training run for the 2010 Winter Olympics competition in Whistler, British Columbia, Canada, on the day of the opening ceremony. He became the fourth athlete to die during preparations for a Winter Olympics, and the seventh athlete to die in either a Summer or Winter Olympic Games.

Estelle Balet was a Swiss freeride snowboarder and two-time world champion in 2015 and 2016 at the Freeride World Tour. She died in an avalanche on 19 April 2016, at the age of 21.

Roderick Anthony Burton II, better known by his stage name Dolla, was an American rapper from Atlanta, Georgia. Burton embarked on his music career in 2000, with hip hop group Da Razkalz Cru, under the pseudonym Bucklyte. The group quickly disbanded, and Burton went on to work as a model for the Sean John clothing line. In 2007, Burton signed to Akon's Konvict Muzik label. Burton released three singles from 2007 to 2009. The first, his commercial debut single "Who the Fuck Is That?", featuring T-Pain and Tay Dizm, charted on the Billboard Hot 100.

Ricardo López, also known as the "Björk stalker", was a Uruguayan-American pest control worker who attempted to kill Icelandic musician Björk in September 1996.