List of Famous people born in Western Cape, South Africa

Handré Pollard is a South African professional rugby union player who currently plays for the South Africa national team and Montpellier in the French Top 14.

Calvin Anele Ngcongca was a South African professional footballer.

James Terence Small was a South African rugby union winger who played for the Springboks. His international debut was against the All Blacks in 1992 and he made his final appearance against Scotland in 1997. In that final test match, he scored his 20th try, becoming the leading Springbok try scorer, eclipsing Danie Gerber's record. He was also the leading try scorer in the 1996 Super 12 season.

Serge Frank Kovaleski is a South African-born American investigative reporter at The New York Times. He contributed to reporting that won The New York Times a Pulitzer Prize for its investigation of the Eliot Spitzer prostitution scandal.

Born in South Africa, Michael Edward Bolus was an artist and teacher who settled in England in 1957 and studied at St Martin's School of Art from 1958 to 1962, studying under Anthony Caro. After a brief period living in Cape Town he returned to London in 1964 to begin a teaching post at St Martin's and the Central School of Art and Design. Bolus had his first UK solo exhibition at Waddington Galleries in 1968, which has exhibited a number of his sculptures since then.

Denis Theodore Goldberg was a South African social campaigner, who was active in the struggle against apartheid. He was accused No. 3 in the Rivonia Trial, alongside the better-known Nelson Mandela and Walter Sisulu, where he was also the youngest of the defendants. He was imprisoned for 22 years, along with other key members of the anti-apartheid movement in South Africa. After his release in 1985 he continued to campaign against apartheid from his base in London with his family, until the apartheid system was fully abolished with the 1994 election. He returned to South Africa in 2002 and founded the non-profit Denis Goldberg Legacy Foundation Trust in 2015. He was diagnosed with lung cancer in July 2019, and died in Cape Town on 29 April 2020.

Eben Etzebeth is a South African professional rugby player who currently plays for the South Africa national team and Toulon in the Top 14 in France. His regular playing position is as a number 4 lock.

Luvo Manyonga is a South African track and field athlete who specialises in the long jump. He won the 2017 World Championship in London and the 2018 Commonwealth Games title in the Gold Coast, Australia. He was the Olympic silver medallist in 2016 in Rio de Janeiro.

Pieter Stephanus du Toit is a South African professional rugby union player. Du Toit plays as a lock or a flanker for the South Africa national team and the Stormers in Super Rugby. After winning the 2019 Rugby World Cup with South Africa, he was awarded the 2019 Men's World Rugby Player of the Year.

Morné Steyn is a South African rugby union player who plays as a fly-half for the Bulls and the South Africa national team.