List of Famous people born in Trujillo, Venezuela

José Gregorio Osuna is a Venezuelan professional baseball outfielder and first baseman for the Tokyo Yakult Swallows of Nippon Professional Baseball (NPB). He has previously played in Major League Baseball (MLB) for the Pittsburgh Pirates.

Fabricio Ojeda was a Venezuelan journalist, politician, and guerrilla leader. He was the President of the Patriotic Junta that organised the movement to end Marcos Pérez Jiménez' dictatorship (1952-1958), and was then elected to the Venezuelan Chamber of Representatives for the Democratic Republican Union (URD), before becoming a leader of the Armed Forces of National Liberation (FALN). He died in custody in 1966.

Humberto Calderón Berti is a Venezuelan geologist, petroleum engineer, diplomat, politician and author, named in 2019 as ambassador to Colombia by interim Venezuelan president Juan Guaido during the 2019 Venezuelan presidential crisis, and welcomed by Carlos Holmes Trujillo, Colombia's foreign minister.

Hugo José García Hernández is a Venezuelan diplomat, a former Ambassador of Venezuela to Russia and the first Ambassador of Venezuela to Abkhazia.