List of Famous people born in Tombouctou Region, Mali

Cissé Mariam Kaïdama Sidibé was a Malian politician and the Prime Minister of Mali at the time of the 2012 Malian coup d'état. She was the first female prime minister in the country's history. She was announced to the position by decree on 3 April 2011, replacing Modibo Sidibé. She held the position for slightly less than a year under the presidency of Amadou Toumani Touré before was removed from office in the 22 March 2012 coup.

Soumaïla Cissé was a Malian politician who served in the government of Mali as Minister of Finance from 1993 to 2000. He thrice stood unsuccessfully as a presidential candidate, in 2002, 2013 and 2018; on all three occasions he was defeated in a second round of voting. Since 2014 he was President of the Union for the Republic and Democracy, a political party.

Khaira Arby, known as The Nightingale of Timbuktu, was a Malian singer.

Askia Muhammad I, born Muhammad ibn Abi Bakr al-Turi or Muhammad Ture, was the first ruler of the Askia Dynasty of the Songhai Empire, reigning from 1493 to 1528. He is also known as Askia the Great, and his name in modern Songhai is Mamar Kassey. Askia Muhammad strengthened his empire and made it the largest empire in West Africa's history. At its peak under his reign, the Songhai Empire encompassed the Hausa states as far as Kano and much of the territory that had belonged to the Songhai empire in the east. His policies resulted in a rapid expansion of trade with Europe and Asia, the creation of many schools, and the establishment of Islam as an integral part of the empire.