List of Famous people born in Tacuarembó Department, Uruguay

Mario Orlando Hardy Hamlet Brenno Benedetti Farrugia , best known as Mario Benedetti, was a Uruguayan journalist, novelist, and poet and an integral member of the Generación del 45. Despite publishing more than 80 books and being published in twenty languages he was not well known in the English-speaking world. In the Spanish-speaking world he is considered one of Latin America's most important writers of the latter half of the 20th century.

Nelson Bonifacio Acosta López, nicknamed Pelado Acosta, is a former Uruguayan footballer. He became a naturalized Chilean citizen in 1984 and managed several football teams. He is now retired.

Fabián Alberto O'Neill Domínguez is a Uruguayan former footballer who played as a midfielder.