List of Famous people born in South Moravian Region, Czech Republic

Libuše Šafránková is a Czech actress. Her husband is actor Josef Abrhám.

Jiří Procházka is a Czech ice dancer. He is the 2005 Czech champion with Diana Janošťáková, 2002 and 2003 champion with Veronika Morávková, and 1999 champion with Gabriela Hrázská.

Daniel Křetínský is a Czech billionaire businessman and lawyer, who is the chief executive officer (CEO) and 94% owner of Energetický a průmyslový holding (EPH), the largest energy group in Central Europe and co-owner and president of football club AC Sparta Prague.

Barbora Krejčíková is a Czech tennis player. Krejčíková has a career-high singles ranking of world No. 33, reached on 31 May 2021, and on 22 October 2018, she became No. 1 in the WTA doubles rankings.

Milan Kundera is a Czech writer who went into exile in France in 1975, becoming a naturalised French citizen in 1981. Kundera's Czechoslovak citizenship was revoked in 1979. He received Czech citizenship in 2019. He "sees himself as a French writer and insists his work should be studied as French literature and classified as such in book stores".

Petr Fiala is a Czech politician, political scientist and university professor who has been Leader of the Civic Democratic Party (ODS) since 2014. He has served as Member of the Chamber of Deputies since 2013. From 2012 to 2013 Fiala was Minister of Education, Youth and Sports in the Cabinet of Prime Minister Petr Nečas.

Lucie Šafářová is a retired Czech tennis player. She won seven singles titles and fifteen doubles titles on WTA Tour. She reached her first Grand Slam quarterfinal at the 2007 Australian Open, upsetting defending champion Amélie Mauresmo in the fourth round, her first Grand Slam semifinal at the 2014 Wimbledon Championships and her first Grand Slam final at the 2015 French Open. She also won the 2015 Australian Open, 2015 French Open, 2016 US Open, 2017 Australian Open and 2017 French Open women's doubles titles partnering with Bethanie Mattek-Sands, as well as the bronze medal in women's doubles at the 2016 Olympic Games alongside her compatriot Barbora Strýcová, upsetting the defending gold medalists Venus and Serena Williams in the first round.

Magdalena Kožená is a Czech mezzo-soprano.

Nicole Melichar-Martinez is an American tennis player who specializes in doubles.

Adam Ondra is a Czech professional rock climber, specializing in lead climbing and bouldering. Rock & Ice magazine described Ondra in 2013 as a prodigy and the leading climber of his generation. Ondra is the only male athlete to have won World Championship titles in both disciplines in the same year (2014), and he is also the only male athlete to have won the World Cup series in both disciplines.