List of Famous people born in South Dakota, United States of America

Dallas Dean Clark is a former American football tight end who played 11 seasons in the National Football League (NFL). He played college football for the University of Iowa, earned unanimous All-American honors, and was recognized as the top college tight end in the nation. He was drafted by the Indianapolis Colts in the first round of the 2003 NFL Draft and he was a member of their Super Bowl XLI championship team against the Chicago Bears. He also played for the Tampa Bay Buccaneers and the Baltimore Ravens.

William Mervin Mills, also known as Tamakoce Te'Hila, is an Oglala Lakota former track and field athlete who won a gold medal in the 10,000 meter run (6.2 mi) at the 1964 Tokyo Olympics. His 1964 victory is considered one of the greatest Olympic upsets because he was a virtual unknown going into the event. He was the first non-European to win the Olympic event and remains the only winner from the Americas. A United States Marine, Billy Mills is a member of the Oglala Sioux Tribe.

Frank Ragnow is an American football center for the Detroit Lions of the National Football League (NFL). He played college football at Arkansas, and was selected by the Lions in the first round of the 2018 NFL Draft.

Mamie Van Doren is an American actress, model, singer, and sex symbol. She is perhaps best remembered for the rock 'n' roll, juvenile delinquency exploitation movie Untamed Youth (1957).

Matthew Lee Guthmiller is an American aviator, YouTuber, entrepreneur, professional speaker, and Massachusetts Institute of Technology alumnus. At age 19, Matt became the youngest person to circumnavigate the globe by air, which he set in a bid to encourage others to pursue ambitious dreams and promote computer science education worldwide. Since then, the record has been beaten by American pilot Mason Andrews. Guthmiller also founded an early iPhone unlocking company, AnySIMiPhones, in 2007 at age 12.

Emily St. James is an American critic, journalist, podcaster, and author. She primarily writes about television. She has written for Vox, The A.V. Club, The Guardian, the Los Angeles Times, Grantland, and Slant, among others.

Ernest Orlando Lawrence was a pioneering American nuclear scientist and winner of the Nobel Prize in Physics in 1939 for his invention of the cyclotron. He is known for his work on uranium-isotope separation for the Manhattan Project, as well as for founding the Lawrence Berkeley National Laboratory and the Lawrence Livermore National Laboratory.

Amy Marie Hill is an American stand-up comedian, actress and voice actress known for often playing grandmother or motherly type roles in both live-action and voice roles. Hill's first major role was as Yung-Hee "Grandma" Kim on All-American Girl where her character became the breakout character of the short-lived television series.

Rachael Bella Zvagelsky known professionally as Rachael Bella, is a retired American actress.

Christopher Cain is an American screenwriter, actor, director, and singer. He married Sharon Thomas in 1969, and adopted her two sons Roger and Dean. The couple's daughter Krisinda Cain Schafer was born in 1973.