List of Famous people born in Santiago Province, Dominican Republic

Natalia Alexandra Gutiérrez Batista, better known by her stage name Natti Natasha, is a Dominican singer and songwriter. She was signed to Don Omar's label Orfanato Music Group. Her debut EP, All About Me, was released on March 28, 2012, by Orfanato Music Group. Her debut album, Iluminatti, was released on February 15, 2019, by Pina Records and Sony Music Latin.

Juan Azarías Pacheco Knipping, known as Johnny Pacheco, is a Dominican musician, arranger, bandleader and record producer. As a flutist and bandleader, Pacheco became one of the leading exponents of the Cuban charanga format in the United States in the early 1960s. As the founder and musical director of Fania Records, Pacheco became a leading figure in the New York salsa scene in the 1960s and 1970s. He popularized the use of the term "salsa" and established the Fania All-Stars to showcase the leading artists of the genre.

Víctor Estrella Burgos is a retired Dominican professional tennis player. In 2014, Estrella became the first Dominican to reach the top 100 in the ATP rankings. He also became the first Dominican player to reach the semifinals in an ATP 250 tournament in Bogota. In 2015, he also became the first tennis player from his country to participate in all four Grand Slams, playing in the Australian Open. In February 2015, he won his first career ATP title at the Ecuador Open, becoming the oldest first-time ATP tour winner in the Open Era. He successfully defended his title and 100% winning record at the event in 2016 and 2017, but lost in the second round in 2018.

José Bernabénis Reyes is a Dominican-American former professional baseball infielder. He played, most notably at shortstop, in Major League Baseball (MLB) for the New York Mets, Miami Marlins, Toronto Blue Jays, and Colorado Rockies.

Amelia Patricia Vega Polanco is a Dominican model, actress, author, singer, and beauty pageant titleholder who was crowned Miss Universe 2003, the first ever Dominican entrant to become Miss Universe. At the age of 18, she was the youngest winner to be crowned Miss Universe since 1994.

Carlos Argelis Gómez Peña, nicknamed Go-Go, is a Dominican former professional baseball outfielder. He played for the New York Mets, Minnesota Twins, Milwaukee Brewers, Houston Astros, Texas Rangers and Tampa Bay Rays. Gómez is a two-time MLB All-Star and a Gold Glove Award winner.

Alex Garcia is a Dominican mixed martial artist who formerly competed in the Welterweight division of the Ultimate Fighting Championship.

Raquel Peña de Antuña is a Dominican politician and academic who currently serves as Vice President of the Dominican Republic since 2020.

Ana Victoria García Pérez, known as Vickiana is a singer, vedette and television presenter. The producer and host of the television program "Vickiana, the forbidden" became very popular in music since 1980. A diabetic, she suffered a myocardial infarction in 1999 and a diabetic coma in 2011.

Rafael Hipólito Mejía Domínguez is a Dominican politician who served as President of the Dominican Republic from 2000 to 2004.