List of Famous people born in Santiago Province, Dominican Republic

Carolina Mejía de Garrigó is a Dominican politician, economist, and businesswoman. She is the current mayor of Santo Domingo. She is the first woman to assume that position.

Luis Andrew Polonia Almonte is a former Major League Baseball outfielder and designated hitter. He currently resides in Santiago, in the Dominican Republic, his hometown.

Manuel Pérez Batista is a Dominican American actor who has appeared in the television series Third Watch and in the film Washington Heights. He is the cousin of Pulitzer Prize-winning author Junot Diaz.

Adriano de Jesús Espaillat Cabral is a Dominican-American politician. He is the U.S. Representative for New York's 13th congressional district and the first formerly undocumented immigrant to ever serve in Congress. Previously, he served as a member of the New York State Senate and as a member of the New York State Assembly.

Juan Antonio Guzman Batista, better known as Juan Guzman, is a Dominican former professional boxer and WBA world Junior Flyweight champion. Due to his high percentage of wins by knockout, he was nicknamed "El Pequeno Foreman". Guzman was born in Santiago de los Caballeros, during the Rafael Trujillo dictatorship era.

Alfredo Simón Cabrera, also known as The Big Pasta, is a Dominican former professional baseball pitcher. He has played in Major League Baseball (MLB) for the Baltimore Orioles, Detroit Tigers and Cincinnati Reds. From 2001 through part of 2004 he pitched under the name Carlos Cabrera.