List of Famous people born in Santiago Metropolitan Region, Chile

Nicolás Ignacio Castillo Mora is a Chilean professional footballer who plays as a striker for Liga MX club América and the Chile national team.

Marcelo Andrés Ríos Mayorga is a former world No. 1 tennis player from Chile. Nicknamed El Chino and El zurdo de Vitacura, he became the first Latin American player to reach the top position on the Association of Tennis Professionals (ATP) singles rankings in 1998. He held the world No. 1 ranking for six weeks. He also held the top ranking in both juniors and seniors. He was the first player to win all three clay-court Masters Series tournaments since the format began in 1990. He was also the third male in the history to complete the Sunshine Double, which he achieved in 1998. Despite winning those five Masters titles, he is the only male player in the open era to have been world No. 1 while never managing to win a Grand Slam singles tournament in his career. He did reach the 1998 Australian Open final, losing to Petr Korda in straight sets.

Ángelo José Henríquez Iturra is a Chilean professional footballer who plays as a striker for Chilean club Universidad de Chile.

Giovanna Jazmín Grandón Caro, also known as Tía Pikachu or Baila Pikachu is a Chilean preschool teacher, political activist, and politician. She obtained great attention during the 2019 Chilean protests, mostly due to her wearing a costume of the character Pikachu from the Japanese media franchise Pokémon. On 16 May 2021, she was elected as a member of the assembly that will write the new Chilean constitution as a response to the 2019 protests.

Ignacio Briones Rojas is a Chilean economist, academic and politician who served as Minister of Finance in the second government of Sebastián Piñera from 2019 until 2021. Prior to this appointment, Ignacio served as Dean of the School of Government of Adolfo Ibáñez University.

Andrés Pío Bernardino Chadwick Piñera is a Chilean right-wing politician and lawyer, member of the Independent Democrat Union (UDI) party. He begun his political career as a supporter of the Pinochet dictatorship, and was present at the Acto de Chacarillas in 1977. Chadwick was elected deputy for the District #33 in 1989, and was re-elected in 1993. In 1997, he was elected senator for the 9th Circumscription of the VI Región del Libertador General Bernardo O'Higgins, and was re-elected in 2005 again. On 18 July 2011 he was invited by his cousin, President Sebastián Piñera, to become Minister Secretary General of Government. He was later appointed Interior Minister on 5 November 2012 and his term ended on 11 March 2014.

Antonia Santa María Monckeberg is a Chilean film, television, and theater actress.

Humberto Maturana is a Chilean biologist and philosopher. Many consider him a member of a group of second-order cybernetics theoreticians such as Heinz von Foerster, Gordon Pask, Herbert Brün and Ernst von Glasersfeld.

Horacio Sanz, better known by his stage name Horatio Sanz, is a Chilean-born American actor and comedian. He was a cast member on Saturday Night Live from 1998 to 2006.

Fernando Francisco González Ciuffardi is a former professional tennis player from Chile. During his career he made it to the quarterfinal round of all four Grand Slam tournaments. He played his only major final at the 2007 Australian Open, losing to top-seeded Roger Federer. He is the fourth male tennis player in history to have won each Olympic medal. The gold medal González won together with Nicolás Massú in the 2004 Olympic doubles competition was the first ever gold medal won by Chile at the Olympics.