List of Famous people born in Santiago Metropolitan Region, Chile

Pablo Ignacio Galdames Millán is a Chilean professional footballer who plays as a midfielder for Serie B club Genoa and the Chile national team.

Óscar Daniel Jadue Jadue is a Chilean architect, sociologist and politician. A member of the Communist Party of Chile (PCCh), Jadue has served as Mayor of Recoleta since 2012. He is currently a presidential candidate in the 2021 Chilean general election. Opinion polling taken during the election has found Jadue to be among the most popular candidates in the race.

Sebastián Ignacio Vegas Orellana is a Chilean footballer who plays as a defender for Liga MX club Monterrey on loan from Mazatlán.

Luz María Valdivieso Ovalle is a Chilean actress.

Pablo Manuel Galdames Díaz is a Chilean former professional footballer who played as a midfielder. He obtained a total number of 22 caps for the Chile national team, scoring two goals between 1995 and 2001.

Jaime José Mañalich Muxi is a Chilean physician (nephrologist), and former Health Minister. He held the position during the first Piñera government (2010-2014) and assumed the role again in June 2019 until he was replaced in June 2020 amidst criticism over his handling of the COVID-19 pandemic in Chile.

Pamela Jiles Moreno is a Chilean journalist and politician, currently serving as a member of the Chamber of Deputies, representing District 12 of the Santiago Metropolitan Region.

Cristián Alexander Zavala Briones is a Chilean professional footballer who plays as a wing-back for Chilean Primera División side Deportes Melipilla.

Nicolás Jarry Fillol is a professional tennis player from Chile. He has won one tournament in singles and two in doubles on the ATP Tour. He achieved his highest ATP singles ranking of 38 in July 2019, after clinching his first ATP title in Bastad. His highest doubles ranking of 40 was achieved in March 2019.

Nicolás Eyzaguirre Guzmán is a Chilean economist, and the former Minister of Education of his country. Previously, he was Chile's Minister of Finance between 2000 and 2006. He is the son of architect Joaquín Eyzaguirre and actress Delfina Guzmán.