List of Famous people born in Santiago de Cuba, Cuba

Marta Hernández Romero, born in Santiago de Cuba, was the mayor of Havana, Cuba, she was elected on 5 March 2011. She is the President of the People's Power Provincial Assembly of the City of Havana (mayor), diputada to the National Assembly, and a member of the Council of State in the VI Legislature. Soon before being elected as the mayor of the city, she was elected as a delegate to the VI Communist Party Congress and frontrunner to be a member of the Central Committee of the Cuban Communist Party.

Yaime Pérez Tellez is a Cuban athlete.

Arnold Alcolea Nuñez is a Cuban former racing cyclist, who competed at the 2012 Summer Olympics, and at the 2014 Central American and Caribbean Games in Veracruz, Mexico.

Daniel Núñez Aguiar is a Cuban weightlifter.

Alpharita Constantia Marley, OD, is a Cuban-born Jamaican singer and the widow of Bob Marley. She was a member of the vocal group the I Threes, along with Marcia Griffiths and Judy Mowatt, who gained recognition as the backing vocalists for Bob Marley and the Wailers.

Gil Cordovés Pérez is a track and road racing cyclist. Formerly a competitor for Cuba, Cordovés thereafter competed for Venezuela.

José-Maria de Heredia was a Cuban-born French Parnassian poet. He was the fifteenth member elected for seat 4 of the Académie française in 1894.

Eduardo René Chibás Ribas was a Cuban politician who used radio to broadcast his political views to the public. He primarily denounced corruption and gangsterism rampant during the governments of Ramón Grau and Carlos Prío which preceded the Batista era. He believed corruption was the most important problem Cuba faced.

Paul Lafargue was a French revolutionary Marxist socialist, political writer, journalist, literary critic, and activist; he was Karl Marx's son-in-law having married his second daughter, Laura. His best known work is The Right to Be Lazy. Born in Cuba to French and Creole parents, Lafargue spent most of his life in France, with periods in England and Spain. At the age of 69, he and 66-year-old Laura died together by a suicide pact.