List of Famous people born in Santiago de Cuba, Cuba

Máximo Francisco Repilado Muñoz Telles, known professionally as "Compay Segundo", was a Cuban trova guitarist, singer and composer.

Leonel Suárez Fajardo is a decathlete from Cuba. He was bronze medalist in the event at the 2012 Summer Olympics, 2008 Summer Olympics and silver medalist at the 2009 World Championships. He won a third consecutive global medal at the 2011 World Championships in Athletics, taking bronze.

Anier Octavio García Ortiz is a Cuban track and field athlete, winner of the 110 metres hurdles at the 2000 Summer Olympics.

Frank País García was a Cuban revolutionary who campaigned for the overthrow of General Fulgencio Batista's government in Cuba. País was the urban coordinator of the 26th of July Movement, and was a key organizer within the urban underground movement, collaborating with Fidel Castro's guerrilla forces which were conducting activities in the Sierra Maestra mountains. País was killed in the streets of Santiago de Cuba by the Santiago police on July 30, 1957.