List of Famous people born in Santiago de Cuba Province, Cuba

Arnold Alcolea Nuñez is a Cuban former racing cyclist, who competed at the 2012 Summer Olympics, and at the 2014 Central American and Caribbean Games in Veracruz, Mexico.

Frank País García was a Cuban revolutionary who campaigned for the overthrow of General Fulgencio Batista's government in Cuba. País was the urban coordinator of the 26th of July Movement, and was a key organizer within the urban underground movement, collaborating with Fidel Castro's guerrilla forces which were conducting activities in the Sierra Maestra mountains. País was killed in the streets of Santiago de Cuba by the Santiago police on July 30, 1957.

Daniel Núñez Aguiar is a Cuban weightlifter.

Yaime Pérez Tellez is a Cuban athlete.

Marta Hernández Romero, born in Santiago de Cuba, was the mayor of Havana, Cuba, she was elected on 5 March 2011. She is the President of the People's Power Provincial Assembly of the City of Havana (mayor), diputada to the National Assembly, and a member of the Council of State in the VI Legislature. Soon before being elected as the mayor of the city, she was elected as a delegate to the VI Communist Party Congress and frontrunner to be a member of the Central Committee of the Cuban Communist Party.

Gil Cordovés Pérez is a track and road racing cyclist. Formerly a competitor for Cuba, Cordovés thereafter competed for Venezuela.

Héctor Vinent Cháron was a Cuban boxer, who won the Light Welterweight Gold medal at the 1992 Summer Olympics and 1996 Summer Olympics. Hector appears in Brin-Jonathan Butler's forthcoming documentary Split Decision. He currently trains athletes at the Istanbul based gym Mugenhous in Turkey.

Leonel Suárez Fajardo is a decathlete from Cuba. He was bronze medalist in the event at the 2012 Summer Olympics, 2008 Summer Olympics and silver medalist at the 2009 World Championships. He won a third consecutive global medal at the 2011 World Championships in Athletics, taking bronze.